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DNA-(apurinic or apyrimidinic site) lyase

Known as: AP Endonuclease, Apurine Apyrimidine Endonuclease, Apurinic Endonuclease 
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA… 
National Institutes of Health

Related topics

Related topics

18 relations
APEX1 geneDNA-(apurinic or apyrimidinic site) lyase activityIn BloodOGG1 gene

Narrower (6)

APEX1 protein, humanAPEX2 protein, humanAPLF protein, humanApex1 protein, rat

Broader (1)

Lyase

Papers overview

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Highly Cited
2015
Highly Cited
2015
Capturing Snapshots of APE1 Processing DNA Damage
DNA apurinic-apyrimidinic (AP) sites are prevalent noncoding threats to genomic stability and are processed by AP endonuclease 1… 
Highly Cited
2007
Highly Cited
2007
Virion-associated Uracil DNA Glycosylase-2 and Apurinic/Apyrimidinic Endonuclease Are Involved in the Degradation of APOBEC3G-edited Nascent HIV-1 DNA*
Cellular cytidine deaminases APOBEC3 family is a group of potent inhibitors for many exogenous and endogenous retroviruses. It… 
Highly Cited
2004
Highly Cited
2004
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition…
Osteosarcoma is the most common highly malignant bone tumor with primary appearance during the second and third decade of life… 
Highly Cited
2003
Highly Cited
2003
Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes
The majority of DNA in eukaryotic cells exists in the highly condensed structural hierarchy of chromatin, which presents a… 
Highly Cited
2001
Highly Cited
2001
A role for p53 in base excision repair
Wild‐type p53 protein can markedly stimulate base excision repair (BER) in vitro, either reconstituted with purified components… 
Highly Cited
1999
Highly Cited
1999
Wavelength dependence of ultraviolet-induced DNA damage distribution: involvement of direct or indirect mechanisms and possible artefacts.
Highly Cited
1997
Highly Cited
1997
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra‐helical deoxyribose at DNA abasic sites
The structure of the major human apurinic/apyrimidinic endonuclease (HAP1) has been solved at 2.2 Å resolution. The enzyme… 
Highly Cited
1980
Highly Cited
1980
Pyrimidine dimer formation and repair in human skin.
Cyclobutyl pyrimidine dimers have been detected in the DNA of human skin following in vivo irradiation with suberythemal doses of… 
Highly Cited
1976
Highly Cited
1976
New class of enzymes acting on damaged DNA
ONE of the major pathways of DNA repair consists of the removal and replacement of damaged nucleotides in non-replicating DNA. In… 
Highly Cited
1975
Highly Cited
1975
Studies on the cleavage of bacteriophage lambda DNA with EcoRI Restriction endonuclease.
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