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APEX2 protein, human

Known as: AP Endonuclease XTH2, APEXL2, APEX nuclease (apurinic-apyrimidinic endonuclease) 2 protein, human 
DNA-(apurinic or apyrimidinic site) lyase 2 (518 aa, ~57 kDa) is encoded by the human APEX2 gene. This protein is involved in DNA repair.
National Institutes of Health

Related topics

Related topics

15 relations
APEX2 geneAPEX2 wt AlleleBase Excision RepairCell Nucleus

Broader (2)

DNA-(apurinic or apyrimidinic site) lyaseExodeoxyribonuclease III

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Altered Endoribonuclease Activity of Apurinic/Apyrimidinic Endonuclease 1 Variants Identified in the Human Population
Apurinic/apyrimidinic endonuclease 1 (APE1) is the major mammalian enzyme in the DNA base excision repair pathway and cleaves the… 
2013
2013
Small Molecule Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)
2011
2011
Nm23-H1 Protein Binds to APE1 at AP Sites and Stimulates AP Endonuclease Activity Following Ionizing Radiation of the Human Lung Cancer A549 Cells
Non-metastatic protein-23 homolog-1 (Nm23-H1) is a multifunctional protein with DNase and histidine protein kinase activities… 
2008
2008
Crystallization and preliminary crystallographic analysis of the catalytic domain of human flap endonuclease 1 in complex with a nicked DNA product: use of a DPCS kit for efficient protein-DNA…
Flap endonuclease 1 (FEN1) is a structure-specific nuclease that removes the RNA/DNA primer associated with Okazaki fragments in… 
2008
2008
Flap endonuclease 1 and its role in eukaryotic DNA metabolism
Flap endonuclease 1 (FEN1) is strongly specific for the substrate structure. The natural substrates of FEN1 are 5′-flap… 
2002
2002
The Type IIs Restriction Endonuclease BspMI Is a Tetramer That Acts Concertedly at Two Copies of an Asymmetric DNA Sequence*
Type IIs endonucleases recognize asymmetric DNA sequences and cleave both strands at fixed positions downstream of the sequence… 
2002
2002
Future directions in protein function prediction
New directions in computational methods for the prediction of protein function are discussed. THEMATICS, a method for the… 
2002
2002
Stimulation of human flap endonuclease 1 by human immunodeficiency virus type 1 integrase: possible role for flap endonuclease 1 in 5'-end processing of human immunodeficiency virus type 1…
Human immunodeficiency virus type 1 (HIV-1) DNA integration intermediates consist of viral and host DNA segments separated by a 5… 
1991
1991
Initiation of the UvrABC nuclease cleavage reaction. Efficiency of incision is not correlated with UvrA binding affinity.
1986
1986
Drosophila apurinic/apyrimidinic DNA endonucleases. Characterization of mechanism of action and demonstration of a novel type of enzyme activity.
Two species of apurinic/apyrimidinic (AP) endonuclease have been purified approximately 400-fold from extracts of Drosophila… 
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