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DNA-(apurinic or apyrimidinic site) lyase

Known as: AP Endonuclease, Apurine Apyrimidine Endonuclease, Apurinic Endonuclease 
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA… 
National Institutes of Health

Related topics

Related topics

18 relations
APEX1 geneDNA-(apurinic or apyrimidinic site) lyase activityIn BloodOGG1 gene

Narrower (6)

APEX1 protein, humanAPEX2 protein, humanAPLF protein, humanApex1 protein, rat

Broader (1)

Lyase

Papers overview

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Highly Cited
2010
Highly Cited
2010
A versatile DNA nanochip for direct analysis of DNA base-excision repair.
Direct observation of enzymes interacting with DNA should be one of the ultimate technologies for investigating the mechanical… 
Highly Cited
2007
Highly Cited
2007
Virion-associated Uracil DNA Glycosylase-2 and Apurinic/Apyrimidinic Endonuclease Are Involved in the Degradation of APOBEC3G-edited Nascent HIV-1 DNA*
Cellular cytidine deaminases APOBEC3 family is a group of potent inhibitors for many exogenous and endogenous retroviruses. It… 
Highly Cited
2003
Highly Cited
2003
Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes
The majority of DNA in eukaryotic cells exists in the highly condensed structural hierarchy of chromatin, which presents a… 
Highly Cited
2003
Highly Cited
2003
Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase
The XPC–HR23B complex recognizes various helix‐distorting lesions in DNA and initiates global genome nucleotide excision repair… 
Review
2001
Review
2001
Enzymology of mitochondrial base excision repair.
Highly Cited
1999
Highly Cited
1999
Wavelength dependence of ultraviolet-induced DNA damage distribution: involvement of direct or indirect mechanisms and possible artefacts.
Highly Cited
1997
Highly Cited
1997
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra‐helical deoxyribose at DNA abasic sites
The structure of the major human apurinic/apyrimidinic endonuclease (HAP1) has been solved at 2.2 Å resolution. The enzyme… 
Highly Cited
1990
Highly Cited
1990
Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV.
DNA damage generated by oxygen radicals includes base-free apurinic/apyrimidinic (AP) sites and strand breaks that bear… 
Highly Cited
1980
Highly Cited
1980
Pyrimidine dimer formation and repair in human skin.
Cyclobutyl pyrimidine dimers have been detected in the DNA of human skin following in vivo irradiation with suberythemal doses of… 
Highly Cited
1976
Highly Cited
1976
New class of enzymes acting on damaged DNA
ONE of the major pathways of DNA repair consists of the removal and replacement of damaged nucleotides in non-replicating DNA. In… 
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