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DEPTOR gene

Known as: DEP.6, FLJ12428, DEP DOMAIN-CONTAINING PROTEIN 6 
This gene plays a role in mTOR-mediated signaling.
National Institutes of Health

Related topics

Related topics

5 relations
ApoptosisDEP Domain-Containing mTOR-Interacting ProteinSignal TransductionSignal Transduction Inhibition

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.
DEP domain-containing mechanistic target of rapamycin (mTOR)-interacting protein (DEPTOR) is an important modulator of mTOR, a… 
2018
2018
OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR
Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates various environmental signals to regulate cell growth and… 
Highly Cited
2015
Highly Cited
2015
Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid.
Highly Cited
2013
Highly Cited
2013
Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity
Obesity may impair protein synthesis rates and cause anabolic resistance to growth factors, hormones, and exercise, ultimately… 
Review
2012
Review
2012
An evolving role for DEPTOR in tumor development and progression.
Deregulation of the mammalian target of rapamycin (mTOR) signaling pathway has been found in a variety of human cancers. However… 
Highly Cited
2011
Highly Cited
2011
mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.
Highly Cited
2011
Highly Cited
2011
Deptor Knockdown Enhances mTOR Activity and Protein Synthesis in Myocytes and Ameliorates Disuse Muscle Atrophy
Deptor is an mTOR binding protein that affects cell metabolism. We hypothesized that knockdown (KD) of Deptor in C2C12 myocytes… 
2011
2011
Overexpression of DEP domain containing mTOR-interacting protein correlates with poor prognosis in differentiated thyroid carcinoma.
DEP domain containing mammalian target of rapamycin (mTOR)-interacting protein (DEPTOR), a recently identified mTOR-interacting… 
Highly Cited
2010
Highly Cited
2010
Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR*
Resveratrol (RSV) is a naturally occurring polyphenol that has been found to exert antioxidant, anti-inflammatory, and… 
Highly Cited
2001
Highly Cited
2001
Discovery and Deployment of Molecular Markers Linked to Fusarium Head Blight Resistance: An Integrated System for Wheat and Barley
Fusarium head blight (FHB), caused by Fusarium graminearum Schwabe [teleomorph Gibberella zeae (Schwein.)], is a devastating… 
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