DEPTOR gene

Known as: DEP.6, FLJ12428, DEP DOMAIN-CONTAINING PROTEIN 6 
This gene plays a role in mTOR-mediated signaling.
National Institutes of Health

Papers overview

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2014
2014
DEPTOR was reported as a naturally occurring inhibitor of mTORC1 and mTORC2. The role of DEPTOR in the growth and survival of… (More)
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Highly Cited
2012
Highly Cited
2012
MLN4924, a newly discovered small molecule inhibitor of NEDD8-activating enzyme (NAE), inactivates Cullin-RING E3 ubiquitin… (More)
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2012
2012
DEP domain-containing mTOR-interacting protein (DEPTOR) inhibits the mechanistic target of rapamycin (mTOR), but its in vivo… (More)
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Highly Cited
2011
Highly Cited
2011
DEPTOR, an inhibitor of mTORC1 and mTORC2, is degraded via ubiquitin-proteasome pathway by an unknown E3 ubiquitin ligase. Here… (More)
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Highly Cited
2011
Highly Cited
2011
The activities of both mTORC1 and mTORC2 are negatively regulated by their endogenous inhibitor, DEPTOR. As such, the abundance… (More)
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Highly Cited
2011
Highly Cited
2011
DEPTOR is a recently identified inhibitor of the mTOR kinase that is highly regulated at the posttranslational level. In response… (More)
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2011
2011
Deptor is an mTOR binding protein that affects cell metabolism. We hypothesized that knockdown (KD) of Deptor in C2C12 myocytes… (More)
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Highly Cited
2010
Highly Cited
2010
Resveratrol (RSV) is a naturally occurring polyphenol that has been found to exert antioxidant, anti-inflammatory, and… (More)
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Highly Cited
2009
Highly Cited
2009
The mTORC1 and mTORC2 pathways regulate cell growth, proliferation, and survival. We identify DEPTOR as an mTOR-interacting… (More)
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Highly Cited
2009
Highly Cited
2009
Dielectrophoresis (DEP) has become a promising technique to separate and identify cells and microparticles suspended in a medium… (More)
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