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Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
Eukaryotic cells contain assemblies of RNAs and proteins termed RNA granules. Many proteins within these bodies contain KH or RRM RNA-binding domains as well as low complexity (LC) sequences ofExpand
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A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of
BackgroundAll archaeal and many bacterial genomes contain Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR-associated (cas) genes that have beenExpand
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Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone
Ghrelin is a 28 amino acid, appetite-stimulating peptide hormone secreted by the food-deprived stomach. Serine-3 of ghrelin is acylated with an eight-carbon fatty acid, octanoate, which is requiredExpand
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PROMALS3D: a tool for multiple protein sequence and structure alignments
Although multiple sequence alignments (MSAs) are essential for a wide range of applications from structure modeling to prediction of functional sites, construction of accurate MSAs for distantlyExpand
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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Innate immune receptor signaling, united Innate immune receptors such as RIG-I, cGAS, and Toll-like receptors bind microbial fragments and alert the immune system to an infection. Each receptor typeExpand
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Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Acetylation of proteins on lysine residues is a dynamic posttranslational modification that is known to play a key role in regulating transcription and other DNA-dependent nuclear processes. However,Expand
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Atypical angiopoietin-like protein that regulates ANGPTL3
  • F. Quagliarini, Yan Wang, +7 authors H. Hobbs
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 12 November 2012
Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Inactivation of ANGPTL3, a gene located in an intron of DOCK7, results in very low levels ofExpand
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COMPASS: a tool for comparison of multiple protein alignments with assessment of statistical significance.
We present a novel method for the comparison of multiple protein alignments with assessment of statistical significance (COMPASS). The method derives numerical profiles from alignments, constructsExpand
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BAP1 loss defines a new class of renal cell carcinoma
The molecular pathogenesis of renal cell carcinoma (RCC) is poorly understood. Whole-genome and exome sequencing followed by innovative tumorgraft analyses (to accurately determine mutant alleleExpand
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AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling
The Vibrio parahaemolyticus type III effector VopS is implicated in cell rounding and the collapse of the actin cytoskeleton by inhibiting Rho guanosine triphosphatases (GTPases). We found that VopSExpand
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