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Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
It is discovered that exposure of cell or tissue lysates to a biotinylated isoxazole (b-isox) chemical precipitated hundreds of RNA-binding proteins with significant overlap to the constituents of RNA granules, offering a framework for understanding the function of LC sequences as well as an organizing principle for cellular structures that are not membrane bound.
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of
It appears most likely that CASS is a prokaryotic system of defense against phages and plasmids that functions via the RNAi mechanism, which seems to involve integration of fragments of foreign genes into archaeal and bacterial chromosomes yielding heritable immunity to the respective agents.
Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.
Data suggest that ABCG5 and ABCG8 normally cooperate to limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol accumulation and atherosclerosis.
Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone
GOAT (Ghrelin O-Acyltransferase), a polytopic membrane-bound enzyme that attaches octanoate to serine-3 of ghrelin, is identified and will facilitate the search for inhibitors that reduce appetite and diminish obesity in humans.
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
This study reveals previously unappreciated roles for lysine acetylation in the regulation of diverse cellular pathways outside of the nucleus, including many longevity regulators and metabolism enzymes.
PROMALS3D: a tool for multiple protein sequence and structure alignments
This work explores the use of 3D structural information to guide sequence alignments constructed by the MSA program PROMALS, and outperforms a number of existing methods for constructing multiple sequence or structural alignments using both reference-dependent and reference-independent evaluation methods.
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
A common signaling mechanism used by all three types of innate immune receptor-adaptor protein pairs to activate IRF3 and generate IFNs is reported, which is important because cells must regulate their IFN production carefully to avoid inflammation and autoimmunity.
Atypical angiopoietin-like protein that regulates ANGPTL3
  • F. Quagliarini, Yan Wang, +7 authors H. Hobbs
  • Biology, Medicine
    Proceedings of the National Academy of Sciences
  • 12 November 2012
ANGPTL8, a paralog of ANGPTL3 that arose through duplication of an ancestral DOCK gene, regulates postprandial TAG and fatty acid metabolism by controlling activation of its progenitor, and perhaps other AngPTLs.
BAP1 loss defines a new class of renal cell carcinoma
The results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities.