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Signal Transduction Inhibition

Known as: inhibition of signal transduction 
Any feature of a cellular signaling process which negatively regulates the further transduction of cell signaling.
National Institutes of Health

Papers overview

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2009
2009
IL-17- and IFN-gamma-secreting T cells play an important role in autoimmune responses in multiple sclerosis and the model system… Expand
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Review
2004
Review
2004
Endocrine therapy is the most effective systemic treatment for patients with hormone-receptor-positive (HR(+)) breast cancer… Expand
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2004
2004
3002 Background: Primary resistance to IM in advanced GIST pts occurs rarely (<15%), but eventually pts may develop secondary… Expand
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Highly Cited
2001
Highly Cited
2001
17-Allylamino-17-demethoxygeldanamycin (17AAG) is a first-in-class heat shock protein 90 (Hsp90) molecular chaperone inhibitor to… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Platelet-derived growth factor (PDGF) has been consistently implicated in the cell proliferation and extracellular… Expand
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Highly Cited
2001
Highly Cited
2001
17-Allylamino-17-demethoxygeldanamycin (17AAG) is a first-in-class heat shock protein 90 (Hsp90) molecular chaperone inhibitor to… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 4
  • figure 3
Is this relevant?
Review
2001
Review
2001
Developing drugs to specifically inhibit oncogenes has been a major goal of cancer research for many years. Identifying the… Expand
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Review
2001
Review
2001
The development of the targeted signal transduction inhibitor imatinib mesylate (formerly STI571, [Gleevec]; Novartis… Expand
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Review
2001
Review
2001
The tyrosine kinase inhibitor, imatinib mesylate (Gleevec, Novartis Pharmaceuticals Corp, East Hanover, NJ) (formerly STI571… Expand
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1997
1997
Irradiation of human lymphocytes (1 cGy X rays, 37 degrees C) or their treatment with 10 microM hydrogen peroxide (30 min at 37… Expand
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