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Gp130 and the interleukin-6 family of cytokines.
TLDR
This paper reviews recent progress in the study of the interleukin-6 family of cytokines and gp130 and describes how the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. Expand
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
TLDR
It is found that mice deficient for CXCR4 die perinatally and display profound defects in the hematopoietic and nervous systems, and Identical defects are observed in mice lacking SDF-1, suggesting a monogamous relationship between CX CR4 and S DF-1. Expand
Impaired immune and acute-phase responses in interleukin-6-deficient mice
TLDR
It is concluded that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes. Expand
A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.
TLDR
Interestingly, NF‐IL6 was shown to bind to the regulatory regions for various acute‐phase protein genes and several other cytokine genes such as TNF, IL‐8 and G‐CSF, implying that NF‐ IL6 has a role in regulation not only for the IL‐6 gene but also for several other genes involved in acute‐ phase reaction, inflammation and hemopoiesis. Expand
IL-6 in inflammation, immunity, and disease.
TLDR
The mechanism for the continual synthesis of IL-6 needs to be elucidated to facilitate the development of more specific therapeutic approaches and analysis of the pathogenesis of specific diseases. Expand
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
TLDR
It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect. Expand
IL‐6: Regulator of Treg/Th17 balance
TLDR
The role of IL‐6 in regulating Th17/Treg balance is reviewed and the critical functions ofIL‐6 and Th17 in immunity and immune‐pathology are described. Expand
The biology of interleukin-6.
TLDR
Human IL-6 (BSF2) was originally identified as a factor in the culture supernatants of mitogen or antigen-stimulated peripheral mononuclear cells, which induced immunoglobulin production in Epstein Barr virus transformed B-cell lines or in Staphylococcus aureus Cowan 1 stimulated normal B cells. Expand
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality.
TLDR
It is demonstrated that Stat3 is essential for the early development of mouse embryos, and analysis of embryos at several gestation times revealed that stat3-deficient embryos showed a rapid degeneration between embryonic days 6.5 and 7.0. Expand
Structure and function of a new STAT-induced STAT inhibitor
TLDR
It is found that SSI-1 messenger RNA was induced by the cytokines interleukins 4 and 6, leukaemia-inhibitory factor (LIF), and granulocyte colony-stimulating factor (G-CSF), and these findings indicate that SSi-1 is responsible for negative-feedback regulation of the JAK–STAT pathway induced by cytokine stimulation. Expand
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