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BGB-283

Known as: BEIGENE-283, Begeine-283, BGB 283 
An inhibitor of the serine/threonine protein kinase B-raf (BRAF) and epidermal growth factor receptor (EGFR), with potential antineoplastic activity… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

BenzimidazolesNaphthyridines
Inhibition of Cell ProliferationReceptor Tyrosine Kinase InhibitionSignal Transduction Inhibition

Papers overview

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2016
2016
BGB-283 Deemed Effective in Phase I Study.
In a phase I trial, BGB-283, which targets the RAF family of proteins, was found to be safe and tolerable-and effective-in… 
2016
2016
Abstract CT002: A Phase IB study of RAF dimer inhibitor BGB-283 in patients with B-RAF or K-RAS/N-RAS mutated solid tumors
Background: BGB-283 is a novel inhibitor of the RAF dimer with potent and reversible inhibitory activities against RAF family… 
2016
2016
Abstract 1230: BGB-283: a novel RAF Dimer inhibitor, displays potent antitumor activity in HCC patient derived xenograft models
Liver cancer has the third highest mortality rate among all cancers in China and hepatocellular carcinoma (HCC) is the most… 
2015
2015
Abstract 669: BGB-283 effectively enhances MEK inhibitor induced tumor suppression in RAS mutant cancers
Mutation in K-RAS, which drives constitutive activation of the mitogen-activated protein kinase (MAPK) signaling pathway, is one… 
2012
2012
Mora Debitoris and the Principle of Strict Liability: Scoin Trading (Pty) Ltd v Bernstein 2011 2 SA 118 (SCA)
Parties generally enter into contractual relations with the sincere intention to fulfil all the obligations created in terms of… 
2009
2009
Bürgerliches Gesetzbuch : mit Allgemeinem Gleichbehandlungsgesetz, BeurkundungsG, BGB-Informationspflichten-Verordnung, Einführungsgesetz, Erbbaurechtsgesetz, Lebenspartnerschaftsgesetz…
2004
2004
Psychiatrie und gerichtliche Psychologie
direkte operative Behandlung (Sympathektomie, Endarteriektomie u.a.) hatte mit 42,2 % etwas bessere Resultate und mit 12,2 % eine… 
2003
2003
Historisch-kritischer Kommentar zum BGB, Bd. I: Allgemeiner Teil, §§ 1-240
2001
2001
Möglichkeiten zur Verminderung rechtlicher und ethischer Probleme bei der Behandlung nicht einwilligungsfähiger oder von Entscheidungsunfähigkeit bedrohter Patienten Vorschläge für eine konzentrierte…
• Ethisch und juristisch ist heutzutage in unserer Gesellschaft unstrittig und allgemein anerkannt, das Entscheidungen uber… 
1996
1996
Notas sobre el nuevo régimen de las asociaciones de utilidad pública
SUMARIO: I. UTILIDAD PUBLICA E INTERÉS PUBLICO: APLICACIÓN DE ESTA TERMINOLOGÍA EN MATERIA DE ASOCIACIONES. 1. Asociaciones de… 
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