DKK1 wt Allele

Known as: UNQ492/PRO1008, DKK-1, Dickkopf Homolog 1 (Xenopus laevis) wt Allele 
Human DKK1 wild-type allele is located in the vicinity of 10q11.2 and is approximately 4 kb in length. This allele, which encodes dickkopf-related… (More)
National Institutes of Health

Related topics

Related topics

11 relations
10q11.2Beta-Catenin Accumulation PathwayDickkopf-Related Protein 1Intercellular Communication Process
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Broader (1)

DKK1 gene

Papers overview

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2012
2012
p38 MAPK in myeloma cells regulates osteoclast and osteoblast activity and induces bone destruction.
p38 mitogen-activated protein kinase (MAPK), which is constitutively activated in human myeloma, has been implicated in bone… (More)
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2012
2012
Adalimumab significantly reduces inflammation and serum DKK-1 level but increases fatty deposition in lumbar spine in active ankylosing spondylitis.
AIM To investigate whether adalimumab is effective for active ankylosing spondylitis (AS) patients and whether it has an impact… (More)
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2010
2010
Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways.
Cancer metastasis is a primary cause of cancer death. Hispolon is an active phenolic compound of Phellinus linteus, a mushroom… (More)
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2010
2010
Hypertension induced by angiotensin II and a high salt diet involves reduced SK current and increased excitability of RVLM projecting PVN neurons.
Although evidence indicates that activation of presympathetic paraventricular nucleus (PVN) neurons contributes to the… (More)
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2009
2009
Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment.
Lytic bone destruction is a hallmark of multiple myeloma (MM) and is because of an uncoupling of bone remodeling. Secretion of… (More)
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2009
2009
Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth.
The protein products of the Dickkopf (DKK) genes are antagonists of Wnt glycoproteins, which participate in tumor development and… (More)
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Highly Cited
2008
Highly Cited
2008
Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma.
OBJECTIVES Lytic bone disease is a hallmark of multiple myeloma (MM) and is caused by osteoclast activation and osteoblast… (More)
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2008
2008
Osteoclasts Are Active in Bone Forming Metastases of Prostate Cancer Patients
BACKGROUND Bone forming metastases are a common and disabling consequence of prostate cancer (CaP). The potential role of… (More)
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2008
2008
SK (KCa2) channels do not control somatic excitability in CA1 pyramidal neurons but can be activated by dendritic excitatory synapses and regulate their impact.
Calcium-activated K(+) channels of the K(Ca)2 type (SK channels) are prominently expressed in the mammalian brain, including… (More)
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2007
2007
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies
Canonical Wnt signalling is an osteoinductive signal that promotes bone repair through acceleration of osteogenic differentiation… (More)
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