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DKK1 wt Allele

Known as: UNQ492/PRO1008, DKK-1, Dickkopf Homolog 1 (Xenopus laevis) wt Allele 
Human DKK1 wild-type allele is located in the vicinity of 10q11.2 and is approximately 4 kb in length. This allele, which encodes dickkopf-related… Expand
National Institutes of Health

Related topics

Related topics

11 relations
10q11.2Beta-Catenin Accumulation PathwayDickkopf-Related Protein 1Intercellular Communication Process
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Broader (1)

DKK1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Berberine promotes bone marrow-derived mesenchymal stem cells osteogenic differentiation via canonical Wnt/β-catenin signaling pathway.
Berberine (BBR) has recently been reported to be extensively used for musculoskeletal disorders such as osteoporosis through… Expand
Highly Cited
2012
Highly Cited
2012
p38 MAPK in myeloma cells regulates osteoclast and osteoblast activity and induces bone destruction.
p38 mitogen-activated protein kinase (MAPK), which is constitutively activated in human myeloma, has been implicated in bone… Expand
2010
2010
Hypertension induced by angiotensin II and a high salt diet involves reduced SK current and increased excitability of RVLM projecting PVN neurons.
Although evidence indicates that activation of presympathetic paraventricular nucleus (PVN) neurons contributes to the… Expand
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Highly Cited
2010
Highly Cited
2010
The effects of shockwave on systemic concentrations of nitric oxide level, angiogenesis and osteogenesis factors in hip necrosis
This study investigated the effects of shockwave on systemic concentrations of nitric oxide (NO) level, angiogenic and osteogenic… Expand
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Highly Cited
2009
Highly Cited
2009
Serum concentrations of DKK‐1 decrease in patients with multiple myeloma responding to anti‐myeloma treatment
Lytic bone destruction is a hallmark of multiple myeloma (MM) and is because of an uncoupling of bone remodeling. Secretion of… Expand
Highly Cited
2008
Highly Cited
2008
Serum concentrations of DKK‐1 correlate with the extent of bone disease in patients with multiple myeloma
Objectives:  Lytic bone disease is a hallmark of multiple myeloma (MM) and is caused by osteoclast activation and osteoblast… Expand
Highly Cited
2008
Highly Cited
2008
SK (KCa2) channels do not control somatic excitability in CA1 pyramidal neurons but can be activated by dendritic excitatory synapses and regulate their impact.
Calcium-activated K(+) channels of the K(Ca)2 type (SK channels) are prominently expressed in the mammalian brain, including… Expand
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Highly Cited
2008
Highly Cited
2008
Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms.
Prostate cancer (PCa) is frequently accompanied by osteosclerotic (i.e., excessive bone production) bone metastases. Although… Expand
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Highly Cited
2008
Highly Cited
2008
Osteoclasts Are Active in Bone Forming Metastases of Prostate Cancer Patients
Background Bone forming metastases are a common and disabling consequence of prostate cancer (CaP). The potential role of… Expand
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Highly Cited
2007
Highly Cited
2007
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies
Canonical Wnt signalling is an osteoinductive signal that promotes bone repair through acceleration of osteogenic differentiation… Expand
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