10q11.2

Two recent genome-wide association studies have independently identified a prostate cancer susceptibility locus on chromosome… Expand

Germline intragenic mutations in PTEN are associated with 80% of patients with Cowden syndrome (CS) and 60% of patients with… Expand

Clinically similar asthma patients may develop airway obstruction by different mechanisms. Asthma treatments that specifically… Expand

The RET proto-oncogene, located on chromosome subband 10q11.2, encodes a receptor tyrosine kinase expressed in tissues and tumors… Expand

Hirschsprung disease (HSCR, aganglionic megacolon) is a common congenital malformation leading to bowel obstruction, with an… Expand

Hirschsprung disease (HSCR) is a common congenital malformation (1 in 5,000 live births) due to the absence of autonomic ganglia… Expand

HIRSCHSPRUNG'S disease is a genetic disorder of neural crest development affecting 1 in 5,000 births. It is characterized by the… Expand

HIRSCHSPRUNG'S disease (HSCR)1 is a common condition (1 in 5,000 live births) resulting in intestinal obstruction in neonates2… Expand

The susceptibility loci for the three multiple endocrine neoplasia (MEN) type 2 syndromes have been mapped to the region of… Expand

Using cosmid clones derived from human ret protooncogene as probes, we determined its chromosome localization by fluorescence in… Expand