Dickkopf-Related Protein 1

Known as: Dickkopf-1, Dkk-1, hDkk-1 
Dickkopf-related protein 1 (266 aa, ~29 kDa) is encoded by the human DKK1 gene. This protein is involved in both receptor binding and cell… (More)

Topic mentions per year

Topic mentions per year

1952-2017
05010019522016

Papers overview

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Highly Cited
2007
Highly Cited
2007
Degenerative and inflammatory joint diseases lead to a destruction of the joint architecture. Whereas degenerative osteoarthritis… (More)
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Highly Cited
2007
Highly Cited
2007
The aim of this study was to determine whether Dickkopf-1 (Dkk-1) expression in breast cancer was associated with bone metastases… (More)
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Highly Cited
2006
Highly Cited
2006
Colorectal cancer is a major cause of cancer death worldwide. A number of key oncogenes and tumor suppressor genes have been… (More)
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Highly Cited
2005
Highly Cited
2005
Wnt glycoproteins regulate homeostasis and development by binding to membrane Frizzled-LRP5/6 receptor complexes. Wnt signaling… (More)
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Highly Cited
2004
Highly Cited
2004
Whereas the adult gastrointestinal epithelium undergoes tremendous self-renewal through active proliferation in crypt stem cell… (More)
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Highly Cited
2001
Highly Cited
2001
Wnt signalling has an important role in cell fate determination, tissue patterning and tumorigenesis. Secreted antagonists of Wnt… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Dickkopf-1 (Dkk-1) is a head inducer secreted from the vertebrate head organizer and induces anterior development by… (More)
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Highly Cited
1999
Highly Cited
1999
Wnt proteins influence many aspects of embryonic development, and their activity is regulated by several secreted antagonists… (More)
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Highly Cited
1998
Highly Cited
1998
The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is… (More)
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Highly Cited
1992
Highly Cited
1992
Since the poor prognosis associated with HER2 amplified breast cancers might be explained by a mechanistic association between… (More)
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