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Advanced Maillard reaction end products are associated with Alzheimer disease pathology.
TLDR
Evidence is presented that antibodies against two Maillard end products, pyrraline and pentosidine, immunocytochemically label neurofibrillary tangles and senile plaques in brain tissue from patients with Alzheimer disease contain modifications typical of advanced Maillard reaction end products. Expand
Prenatal exposure to bisphenol A up‐regulates immune responses, including T helper 1 and T helper 2 responses, in mice
TLDR
The results suggest that prenatal exposure to BPA may result in the up‐regulation of immune responses, especially Th1 responses, in adulthood. Expand
Insulin degludec/insulin aspart versus biphasic insulin aspart 30 in Asian patients with type 2 diabetes inadequately controlled on basal or pre-/self-mixed insulin: a 26-week, randomised,
TLDR
In Asian adults with T2DM, IDegAsp BID effectively improves long-term glycaemic control, and compared to BIAsp 30, provides superior reductions in FPG with a lower dose, and numerically less nocturnal hypoglycaemia. Expand
Effects of in utero exposure to nanoparticle-rich diesel exhaust on testicular function in immature male rats.
TLDR
It is suggested that prenatal exposure to NR-DE or F-DE leads to endocrine disruption after birth and suppresses testicular function in male rats and the nanoparticles in DE did not contribute to the observed reproductive toxicity. Expand
Estrogenic and anti-androgenic activity of nitrophenols in diesel exhaust particles (DEP).
TLDR
Anti-androgenicity is found in all four nitrophenols isolated from diesel exhaust particles (DEP) because these compounds are alkylphenolic derivatives that might mimic hormones. Expand
Advanced Maillard Reaction End Products, Free Radicals, and Protein Oxidation in Alzheimer's Disease a
TLDR
Evidence is presented that the seminal features of Alzheimer’s disease, including amyloid-P deposition, neurofibrillary tangle formation, degeneration of specific neuronal populations, and the persistence of the pathological lesions in vivo and their relative insolubility in vitro may all be related to specific oxidative stress-type mechanisms. Expand
ELISA of pentosidine, an advanced glycation end product, in biological specimens.
TLDR
This ELISA provides a new tool for assessing the role of the advanced Maillard reaction in aging and age-related diseases and pentosidine values in digested human plasma correlating with those measured by HPLC. Expand
Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormone.
TLDR
Disruption of testosterone biosynthesis by NR-DE exposure may be a mode of action for reproductive toxicity, which may, in part, be regulated by increasing StAR and P450scc expressions via GH signalling. Expand
Effect of methotrexate on Th1 and Th2 immune responses in mice
TLDR
The results indicate that MTX appears to suppress Th1 and, to a lesser extent, Th2 immune responses and its anti‐arthritic effect on human rheumatoid arthritis might be at least in part explained by down‐regulation of Th1 responses involved in the disease. Expand
Identification of pentosidine as a native structure for advanced glycation end products in beta-2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis.
TLDR
Findings implicate a potential link of glycoxidation products in long-lived beta-2m-containing amyloid fibrils to the pathogenesis of DRA. Expand
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