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DCK gene

Known as: DCK, DEOXYCYTIDINE KINASE, Deoxycytidine Kinase Gene 
This gene is involved in deoxyribonucleoside phosphorylation.
National Institutes of Health

Related topics

Related topics

5 relations
Deoxycytidine KinaseDrug EffluxDrug resistanceLeukemia, Myelocytic, Acute

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides.
Biological molecules are predominantly enantioselective. Yet currently two nucleoside analogue prodrugs (3TC and FTC) with… 
Highly Cited
2003
Highly Cited
2003
Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.
2002
2002
Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines.
Highly Cited
1999
Highly Cited
1999
Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562
Resistant variants of the human leukaemic line K562 were developed using selection with the deoxynucleoside analogues cytosine… 
Review
1994
Review
1994
Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy.
Highly Cited
1989
Highly Cited
1989
Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase.
Highly Cited
1989
Highly Cited
1989
Human T-lymphoblast deoxycytidine kinase: purification and properties.
Previous observations present tremendous variations in the properties of deoxycytidine kinase. To clarify the properties and… 
1989
1989
Human deoxycytidine kinase: kinetic mechanism and end product regulation.
The kinetic properties of the monomeric deoxycytidine kinase (EC 2.7.1.74) from leukemic human T-lymphoblasts have been… 
Highly Cited
1981
Highly Cited
1981
Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases.
The biochemical basis of cellular resistance to 9-beta-D-arabinofuranosyladenine (ara-A) and its natural purine derivative… 
Highly Cited
1981
Highly Cited
1981
A biochemical genetic study of the role of specific nucleoside kinases in deoxyadenosine phosphorylation by cultured human cells.
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