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DCK gene

Known as: DCK, DEOXYCYTIDINE KINASE, Deoxycytidine Kinase Gene 
This gene is involved in deoxyribonucleoside phosphorylation.
National Institutes of Health

Related topics

Related topics

5 relations
Deoxycytidine KinaseDrug EffluxDrug resistanceLeukemia, Myelocytic, Acute

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene
BackgroundGemcitabine is an analogue of deoxycytidine with activity against several solid tumors. In order to elucidate the… 
Highly Cited
1999
Highly Cited
1999
Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562
Resistant variants of the human leukaemic line K562 were developed using selection with the deoxynucleoside analogues cytosine… 
Highly Cited
1992
Highly Cited
1992
Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.
Highly Cited
1992
Highly Cited
1992
Nucleotide specificity of human deoxycytidine kinase.
The ability of deoxycytidine kinase (dCK) to phosphorylate 2'-deoxycytidine (dCyd) and its analogs in the presence of eight… 
Highly Cited
1991
Highly Cited
1991
Cloning and expression of human deoxycytidine kinase cDNA.
Deoxycytidine (dCyd) kinase is required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs… 
Highly Cited
1988
Highly Cited
1988
Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.
Highly Cited
1982
Highly Cited
1982
Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells.
Highly Cited
1981
Highly Cited
1981
Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases.
The biochemical basis of cellular resistance to 9-beta-D-arabinofuranosyladenine (ara-A) and its natural purine derivative… 
Highly Cited
1980
Highly Cited
1980
Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.
An inherited deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) produces selective lymphopenia and… 
Highly Cited
1980
Highly Cited
1980
Metabolism and chemotherapeutic activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine against murine leukemia L1210 and evidence for its phosphorylation by deoxycytidine kinase.
The 2-fluoro derivative of 9-beta-D-arabinofuranosyladenine (2-F-ara-A) and its soluble 5'-formate and 5'-phosphate derivatives… 
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