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Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development
TLDR
The replication dynamics in cells in which a regulator of S phase entry and cell proliferation, the Rb-E2F pathway, is aberrantly activated are studied to suggest a model for early oncogenesis in which uncoordinated activation of factors regulating cell proliferation leads to insufficient nucleotides that fail to support normal replication and genome stability. Expand
Metabolism of 2',2'-difluoro-2'-deoxycytidine and radiation sensitization of human colon carcinoma cells.
TLDR
It is suggested that the profound depletion by dFdCyd of dATP and dGTP pools in HT-29 compared to leukemic cells accounts for the superiority of this agent in solid tumors versus leukemias. Expand
Laboratory and clinical evidence of synergistic cytotoxicity of sequential treatment with gemcitabine followed by docetaxel in the treatment of sarcoma.
TLDR
The combination of gemcitabine and docetaxel seems to be active in a variety of sarcomas, with mixed results in cell culture studies and a multicenter, randomized clinical trial in soft tissue sarcoma. Expand
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells
TLDR
A novel functional link between C-MYC and dNTP metabolism is established and its role in proliferation of tumor cells is identified. Expand
The role of cell cycle progression in radiosensitization by 2',2'-difluoro-2'-deoxycytidine.
TLDR
The results suggest that the G1 block in D54 cells resulting from wild-type p53 induction prevented radiosensitization by dFdCyd, which would have indicated that U251 cells were more sensitive to the cytotoxicity of dFfDcyd, and that dFDCyd was able to radiosensite these cells. Expand
Radiosensitization of pancreatic cancer cells by 2',2'-difluoro-2'-deoxycytidine.
TLDR
Findings demonstrate that dFdCyd is a potent radiation sensitizer of human pancreatic cancer cells and support the development of a clinical protocol using combined dFDCyd and radiation therapy in the treatment of Pancic cancer. Expand
Cloning and expression of human deoxycytidine kinase cDNA.
TLDR
Findings document that this cDNA encodes the T-lymphoblast dCyd kinase responsible for the phosphorylation of dAdo and dGuo as well as dDCyd and arabinofuranosylcytosine. Expand
Radiation concurrent with gemcitabine for locally advanced head and neck cancer: a phase I trial and intracellular drug incorporation study.
TLDR
A high rates of acute and late mucosa-related DLT and a high rate of complete tumor response were observed in this regimen at the dose levels of 50 to 300 mg/m(2), which also resulted in similar, subcytotoxic intracellular dFdCTP concentrations. Expand
N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers.
TLDR
G5-NAcGal conjugates function as targeted carriers for selective delivery of chemotherapeutic agents into hepatic cancer cells by coupling N-acetylgalactosamine to generation 5 of poly(amidoamine) dendrimers via peptide and thiourea linkages. Expand
Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinase.
TLDR
The (+)- and (-)-enantiomers of FTC and BCH-189 are the first nucleoside analogs for which the authors have observed lower apparent kinetic constants for this enzyme in the presence of ATP compared to UTP. Expand
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