• Publications
  • Influence
Vedolizumab as induction and maintenance therapy for ulcerative colitis.
BACKGROUND Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative colitis. METHODS We conducted two integrated randomized, double-blind,Expand
  • 1,364
  • 74
  • PDF
Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin.
BACKGROUND Selective blockade of interactions between leukocytes and vascular endothelium in the gut is a promising strategy for the treatment of inflammatory bowel diseases. METHODS We conducted aExpand
  • 642
  • 29
The safety of vedolizumab for ulcerative colitis and Crohn's disease
Objective Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab.Expand
  • 386
  • 13
  • PDF
Effects of vedolizumab induction therapy for patients with Crohn's disease in whom tumor necrosis factor antagonist treatment failed.
BACKGROUND & AIMS There is an increasing need for new treatments for patients with Crohn's disease (CD) in whom previous therapy with tumor necrosis factor (TNF) antagonists has failed. We performedExpand
  • 444
  • 11
Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases.
Adenosine kinase catalyzes the phosphorylation of adenosine to AMP and hence is a potentially important regulator of extracellular adenosine concentrations. Despite extensive characterization of theExpand
  • 125
  • 9
The role of adenosine and 2'-deoxyadenosine in mammalian cells.
Biochemical Effects . h�:�iJ/::;;�·;h�;i�:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: PP-ribose-P metabolism . S-Adenosylhomocysteine metabolism .Expand
  • 460
  • 8
Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome.
Different brain regions were removed post mortem from three patients with the Lesch-Nyhan syndrome and were examined for alterations in hypoxanthine-guanine phosphoribosyl transferase (HGPRT),Expand
  • 344
  • 6
Human placental adenosine kinase. Kinetic mechanism and inhibition.
The kinetic properties of human placental adenosine kinase, purified 3600-fold, were studied. The reaction velocity had an absolute requirement for magnesium and varied with the pH. Maximal activityExpand
  • 85
  • 6
Management of gout.
GOUT is a term describing a heterogeneous group of diseases that, in full development, are manifested by (1) an increase in the serum urate concentration, (2) recurrent attacks of a characteristicExpand
  • 182
  • 6
High Km soluble 5'-nucleotidase from human placenta. Properties and allosteric regulation by IMP and ATP.
A human placental soluble "high Km" 5'-nucleotidase has been separated from "low Km" 5'-nucleotidase and nonspecific phosphatase by AMP-Sepharose affinity chromatography. The enzyme was purifiedExpand
  • 76
  • 6
  • PDF