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- Publications
- Influence
Vedolizumab as induction and maintenance therapy for ulcerative colitis.
- B. Feagan, P. Rutgeerts, +13 authors A. Parikh
- Medicine
- The New England journal of medicine
- 21 August 2013
BACKGROUND
Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative colitis.
METHODS
We conducted two integrated randomized, double-blind,… Expand
Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin.
- B. Feagan, G. Greenberg, +10 authors M. Vandervoort
- Medicine
- The New England journal of medicine
- 16 June 2005
BACKGROUND
Selective blockade of interactions between leukocytes and vascular endothelium in the gut is a promising strategy for the treatment of inflammatory bowel diseases.
METHODS
We conducted a… Expand
The safety of vedolizumab for ulcerative colitis and Crohn's disease
- Jean-Frédéric Colombel, B. Sands, +11 authors B. Feagan
- Medicine
- Gut
- 18 February 2016
Objective Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab.… Expand
Effects of vedolizumab induction therapy for patients with Crohn's disease in whom tumor necrosis factor antagonist treatment failed.
- B. Sands, B. Feagan, +11 authors S. Hanauer
- Medicine
- Gastroenterology
- 1 September 2014
BACKGROUND & AIMS
There is an increasing need for new treatments for patients with Crohn's disease (CD) in whom previous therapy with tumor necrosis factor (TNF) antagonists has failed. We performed… Expand
Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases.
- J. Spychala, N. Datta, +4 authors B. Mitchell
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 6 February 1996
Adenosine kinase catalyzes the phosphorylation of adenosine to AMP and hence is a potentially important regulator of extracellular adenosine concentrations. Despite extensive characterization of the… Expand
The role of adenosine and 2'-deoxyadenosine in mammalian cells.
Biochemical Effects . h�:�iJ/::;;�·;h�;i�:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: PP-ribose-P metabolism . S-Adenosylhomocysteine metabolism .… Expand
Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome.
- K. Lloyd, O. Hornykiewicz, +6 authors I. Fox
- Biology, Medicine
- The New England journal of medicine
- 5 November 1981
Different brain regions were removed post mortem from three patients with the Lesch-Nyhan syndrome and were examined for alterations in hypoxanthine-guanine phosphoribosyl transferase (HGPRT),… Expand
Human placental adenosine kinase. Kinetic mechanism and inhibition.
- T. Palella, C. Andres, I. Fox
- Medicine, Chemistry
- The Journal of biological chemistry
- 10 June 1980
The kinetic properties of human placental adenosine kinase, purified 3600-fold, were studied. The reaction velocity had an absolute requirement for magnesium and varied with the pH. Maximal activity… Expand
Management of gout.
GOUT is a term describing a heterogeneous group of diseases that, in full development, are manifested by (1) an increase in the serum urate concentration, (2) recurrent attacks of a characteristic… Expand
High Km soluble 5'-nucleotidase from human placenta. Properties and allosteric regulation by IMP and ATP.
- J. Spychała, V. Madrid-Marina, I. Fox
- Medicine, Chemistry
- The Journal of biological chemistry
- 15 December 1988
A human placental soluble "high Km" 5'-nucleotidase has been separated from "low Km" 5'-nucleotidase and nonspecific phosphatase by AMP-Sepharose affinity chromatography. The enzyme was purified… Expand