• Publications
  • Influence
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies.
PS-341 showed activity against refractory multiple myeloma and possibly non-Hodgkin's lymphoma in this study, and merits further investigation in these populations. Expand
The 5'-nucleotidases as regulators of nucleotide and drug metabolism.
The physiological role of the 5'-nucleotidases will be covered, as will the evidence that these enzymes can mediate resistance to nucleoside analogues, a class of anticancer and antiviral agents that rely on the nucleosid kinases for phosphorylation to their active forms. Expand
Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine.
Alemtuzumab has significant activity in poor-prognosis, fludarabine-treated CLL patients, however, because of a relatively high incidence of opportunistic infections accompanying profound lymphopenia, future protocols should include mandatory prophylaxis. Expand
Human Cytosolic 5′-Nucleotidase I
Data indicate that cN-I may play an important role in the regulation of physiological pyrimidine nucleotide pools and may also alter the therapeutic efficacy of certain nucleoside analogs. Expand
Regulation of the Interaction of Inosine Monophosphate Dehydrogenase with Mycophenolic Acid by GTP*
It is concluded that intracellular GTP acts as an antagonist to MPA by directly binding to IMPDH and reversing the conformational changes in the protein. Expand
Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies.
Bortezomib/PegLD was safely administered in this study with promising antitumor activity, supporting further testing of this regimen and pharmacokinetic and pharmacodynamic studies did not find significant drug interactions between these agents. Expand
Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase
  • K. Mahajan, B. Mitchell
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 5 September 2003
It is concluded that hPso4 plays a major and previously undefined role in mammalian DNA DSB repair. Expand
Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases.
Adenosine kinase is a structurally distinct mammalian nucleoside kinase that appears to be akin to sugar kinases of microbial origin and set it apart from this family of structurally and functionally related proteins. Expand
Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801.
Nelarabine is well tolerated and has significant antitumor activity in relapsed or refractory T-ALL and T-LBL and 1-year overall survival was 28% (95% CI, 15, 43%). Expand
Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.
It is shown here that after exposure of cells to ionizing radiation (IR), levels of pol mu protein increase, and this data support an important role for pol mu in the end-joining pathway for repair of double-strand breaks. Expand