Deoxycytidine Kinase

Known as: 2'-Deoxycytidine Kinase, Kinase, Deoxycytidine, DCK 
An enzyme that catalyzes reversibly the phosphorylation of deoxycytidine with the formation of a nucleoside diphosphate and deoxycytidine… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
RNA-binding protein HuR binds U- or AU-rich sequences in the 3'-untranslated regions of target mRNAs, stabilizing them and/or… (More)
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Highly Cited
2009
Highly Cited
2009
5-aza-2'-deoxycytidine (DAC) is approved for the treatment of myelodysplastic syndromes, but resistance to this agent is common… (More)
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Highly Cited
2006
Highly Cited
2006
Gemcitabine is considered the standard first-line therapy for patients with advanced pancreatic cancer. More recent strategies… (More)
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Highly Cited
2004
Highly Cited
2004
HIV-1 and other retroviruses occasionally undergo hypermutation, characterized by a high rate of G-to-A substitution. Recently… (More)
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Highly Cited
2002
Highly Cited
2002
Deoxycytidine kinase (dCK) is essential for the phosphorylation of gemcitabine (2',2'-difluorodeoxycytidine), a deoxycytidine… (More)
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1998
1998
Deoxycytidine kinase (dCK) catalyzes the rate-limiting step of the deoxynucleoside salvage pathway in mammalian cells and plays a… (More)
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1997
1997
Human deoxyribonucleoside kinases are required for the pharmacological activity of several clinically important anticancer and… (More)
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1993
1993
Deoxycytidine kinase (dCK) and deaminase (dCDA) are both key enzymes in the activation and inactivation, respectively, of several… (More)
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Highly Cited
1993
Highly Cited
1993
Phosphorylation of cytosine analogs by deoxycytidine kinase (dCK) and deamination by cytidine deaminase (CDA) are two important… (More)
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1992
1992
The ability of deoxycytidine kinase (dCK) to phosphorylate 2'-deoxycytidine (dCyd) and its analogs in the presence of eight… (More)
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