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Deoxycytidine Kinase

Known as: 2'-Deoxycytidine Kinase, Kinase, Deoxycytidine, DCK 
An enzyme that catalyzes reversibly the phosphorylation of deoxycytidine with the formation of a nucleoside diphosphate and deoxycytidine… 
National Institutes of Health

Related topics

Related topics

17 relations
DCK geneDrug EffluxDrug resistanceEnzyme Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides.
Biological molecules are predominantly enantioselective. Yet currently two nucleoside analogue prodrugs (3TC and FTC) with… 
2006
2006
(+/-)-3'-O, 4'-O-dicynnamoyl-cis-khellactone, a derivative of (+/-)-praeruptorin A, reverses P-glycoprotein mediated multidrug resistance in cancer cells.
Highly Cited
1998
Highly Cited
1998
The Intracellular Localization of Deoxycytidine Kinase*
Deoxycytidine kinase (dCK) catalyzes the rate-limiting step of the deoxynucleoside salvage pathway in mammalian cells and plays a… 
Review
1994
Review
1994
Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy.
Highly Cited
1994
Highly Cited
1994
Structural analysis of the deoxycytidine kinase gene in patients with acute myeloid leukemia and resistance to cytosine arabinoside.
Deficiency of deoxycytidine kinase (dCK) activity represents one possible cause of resistance to cytosine arabinoside (ara-C… 
1993
1993
Genomic structure and chromosomal localization of the human deoxycytidine kinase gene.
Deoxycytidine kinase (NTP:deoxycytidine 5'-phosphotransferase, EC 2.7.1.74) is an enzyme that catalyzes phosphorylation of… 
Highly Cited
1982
Highly Cited
1982
Initiation of adenovirus DNA replication: detection of covalent complexes between nucleotide and the 80-kilodalton terminal protein
We have previously shown that the 5'-terminal deoxycytidine residue of each nascent adenovirus 5 DNA strand synthesized in vitro… 
Review
1982
Review
1982
Agraphesthesia A disorder of directional cutaneous kinesthesia or a disorientation in cutaneous space
1972
1972
The selective excision of arylalkylated products from the DNA of Escherichia coli treated with the carcinogen 7-bromomethylbenz(a)anthracene.
1968
1968
Effects of cytosine arabinoside on the cell viability and uptake of deoxypyrimidine nucleosides in L5178Y cells.
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