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Cytochrome P-450 CYP2E1

Known as: Cytochrome P 450 IIE1, N Nitrosodimethylamine Demethylase, CYP2E1 
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include… 
National Institutes of Health

Related topics

Related topics

27 relations
4-nitrophenol 2-monooxygenase activityAromataseCYP2C18 protein, humanCYP2C19 gene

Broader (5)

Aryl Hydrocarbon HydroxylasesCytochrome P450Mixed Function OxygenasesOxidoreductases, N-Demethylating

Narrower (1)

Cytochrome P450 2E1, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine
Review
2005
Review
2005
Alcohol and liver cancer.
Highly Cited
2003
Highly Cited
2003
Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice.
Highly Cited
2001
Highly Cited
2001
Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.
Earlier studies have shown highly exaggerated mechanism-based liver injury of thioacetamide (TA) in rats following moderate diet… 
Highly Cited
2001
Highly Cited
2001
Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer.
Highly Cited
2000
Highly Cited
2000
Interindividual variance of cytochrome P450 forms in human hepatic microsomes: correlation of individual forms with xenobiotic metabolism and implications in risk assessment.
Differences in biotransformation activities may alter the bioavailability or efficacy of drugs, provide protection from certain… 
Highly Cited
1998
Highly Cited
1998
Co-localization of P450 enzymes in the rat substantia nigra with tyrosine hydroxylase
Highly Cited
1995
Highly Cited
1995
CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil.
Msp I polymorphism and exon 7 Ile-Val polymorphism of CYP1A1, and Rsa I polymorphism of CYP2E1 were studied in lung cancer… 
Highly Cited
1994
Highly Cited
1994
Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: possible relevance to low smoking exposure.
Polymorphic metabolism of certain chemical carcinogens may result in differences in susceptibility to cancers. Human CYP2E1… 
Highly Cited
1984
Highly Cited
1984
Studies on the mechanisms of induction of N-nitrosodimethylamine demethylase by fasting, acetone, and ethanol.
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