Cytochrome P-450 CYP2E1

Known as: Cytochrome P 450 IIE1, N Nitrosodimethylamine Demethylase, CYP2E1 
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include… (More)
National Institutes of Health

Papers overview

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Review
2006
Review
2006
The involvement of free radical mechanisms in the pathogenesis of alcoholic liver disease (ALD) is demonstrated by the detection… (More)
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Review
2006
Review
2006
A causal association has been established between alcohol consumption and cancers of the oral cavity, pharynx, larynx, oesophagus… (More)
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Review
2003
Review
2003
The importance of the isoform CYP2E1 of the human cytochrome P-450 superfamily of enzymes for occupational and environmental… (More)
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Highly Cited
2001
Highly Cited
2001
Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on… (More)
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Review
2001
Review
2001
Induction of CYP2E1 by ethanol is one of the central pathways by which ethanol generates a state of oxidative stress in… (More)
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Highly Cited
2000
Highly Cited
2000
Nonalcoholic steatohepatitis (NASH) and alcoholic liver disease have similar pathological features. Because CYP2E1 plays a key… (More)
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Highly Cited
1996
Highly Cited
1996
CYP2El, a cytochrome P-450 that is well conserved across mammalian species, metabolizes ethanol and many low molecular weight… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND & AIMS Nonalcoholic steatohepatitis is morphologically identical to alcoholic hepatitis and has multiple etiologic… (More)
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Highly Cited
1995
Highly Cited
1995
In the present study, we demonstrate that ethanol induces CYP2E1 by protein stabilization in vivo. The control half-life of… (More)
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Highly Cited
1991
Highly Cited
1991
The role of human cytochrome P-450 IIE1 (P-450 IIE1) in the oxidation of a number of suspect carcinogens was examined by using a… (More)
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