Cytochrome P-450 CYP2E1

Known as: Cytochrome P 450 IIE1, N Nitrosodimethylamine Demethylase, CYP2E1 
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include… (More)
National Institutes of Health

Related topics

Related topics

27 relations
4-nitrophenol 2-monooxygenase activityAromataseCYP2C18 protein, humanCYP2C19 gene
(More)

Broader (5)

Aryl Hydrocarbon HydroxylasesCytochrome P450Mixed Function OxygenasesOxidoreductases, N-Demethylating
(More)

Narrower (1)

Cytochrome P450 2E1, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Alcohol, oxidative stress and free radical damage.
The involvement of free radical mechanisms in the pathogenesis of alcoholic liver disease (ALD) is demonstrated by the detection… (More)
Is this relevant?
Review
2006
Review
2006
Alcohol and cancer.
A causal association has been established between alcohol consumption and cancers of the oral cavity, pharynx, larynx, oesophagus… (More)
Is this relevant?
Review
2003
Review
2003
The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine.
The importance of the isoform CYP2E1 of the human cytochrome P-450 superfamily of enzymes for occupational and environmental… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Metabolic gene polymorphism frequencies in control populations.
Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on… (More)
Is this relevant?
Review
2001
Review
2001
CYP2E1-dependent toxicity and oxidative stress in HepG2 cells.
Induction of CYP2E1 by ethanol is one of the central pathways by which ethanol generates a state of oxidative stress in… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
Nonalcoholic steatohepatitis (NASH) and alcoholic liver disease have similar pathological features. Because CYP2E1 plays a key… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Role of CYP2E1 in the hepatotoxicity of acetaminophen.
CYP2El, a cytochrome P-450 that is well conserved across mammalian species, metabolizes ethanol and many low molecular weight… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation.
BACKGROUND & AIMS Nonalcoholic steatohepatitis is morphologically identical to alcoholic hepatitis and has multiple etiologic… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1.
In the present study, we demonstrate that ethanol induces CYP2E1 by protein stabilization in vivo. The control half-life of… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.
The role of human cytochrome P-450 IIE1 (P-450 IIE1) in the oxidation of a number of suspect carcinogens was examined by using a… (More)
Is this relevant?