Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 227,467,215 papers from all fields of science
Search
Sign In
Create Free Account
Cytochrome P-450 CYP2E1
Known as:
Cytochrome P 450 IIE1
, N Nitrosodimethylamine Demethylase
, CYP2E1
Expand
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
27 relations
4-nitrophenol 2-monooxygenase activity
Aromatase
CYP2C18 protein, human
CYP2C19 gene
Expand
Broader (5)
Aryl Hydrocarbon Hydroxylases
Cytochrome P450
Mixed Function Oxygenases
Oxidoreductases, N-Demethylating
Expand
Narrower (1)
Cytochrome P450 2E1, human
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine
Meenal M. Joshi
,
R. Tyndale
Neuropharmacology
2006
Corpus ID: 23383843
Review
2005
Review
2005
Alcohol and liver cancer.
I. Mckillop
,
L. Schrum
Alcohol
2005
Corpus ID: 21998719
Highly Cited
2003
Highly Cited
2003
Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice.
C. Cheung
,
T. Akiyama
,
G. Kudo
,
F. Gonzalez
Biochemical Pharmacology
2003
Corpus ID: 5684694
Highly Cited
2001
Highly Cited
2001
Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.
Shashi K. Ramaiah
,
U. Apte
,
H. Mehendale
Drug Metabolism And Disposition
2001
Corpus ID: 29734773
Earlier studies have shown highly exaggerated mechanism-based liver injury of thioacetamide (TA) in rats following moderate diet…
Expand
Highly Cited
2001
Highly Cited
2001
Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer.
S. Liu
,
Jong Y. Park
,
S. Schantz
,
J. Stern
,
P. Lazarus
Oral Oncology
2001
Corpus ID: 10681808
Highly Cited
2000
Highly Cited
2000
Interindividual variance of cytochrome P450 forms in human hepatic microsomes: correlation of individual forms with xenobiotic metabolism and implications in risk assessment.
J. Snawder
,
John C. Lipscomb
Regulatory toxicology and pharmacology : RTP
2000
Corpus ID: 15174379
Differences in biotransformation activities may alter the bioavailability or efficacy of drugs, provide protection from certain…
Expand
Highly Cited
1998
Highly Cited
1998
Co-localization of P450 enzymes in the rat substantia nigra with tyrosine hydroxylase
P. Watts
,
A. G. Riedl
,
+4 authors
C. Marsden
Neuroscience
1998
Corpus ID: 635756
Highly Cited
1995
Highly Cited
1995
CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil.
Haruhiko Sugimura
,
G. S. Hamada
,
+4 authors
S. Tsugane
Pharmacogenetics (London)
1995
Corpus ID: 9541746
Msp I polymorphism and exon 7 Ile-Val polymorphism of CYP1A1, and Rsa I polymorphism of CYP2E1 were studied in lung cancer…
Expand
Highly Cited
1994
Highly Cited
1994
Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: possible relevance to low smoking exposure.
F. Uematsu
,
S. Ikawa
,
+6 authors
Minro Watanabe
Pharmacogenetics (London)
1994
Corpus ID: 1599290
Polymorphic metabolism of certain chemical carcinogens may result in differences in susceptibility to cancers. Human CYP2E1…
Expand
Highly Cited
1984
Highly Cited
1984
Studies on the mechanisms of induction of N-nitrosodimethylamine demethylase by fasting, acetone, and ethanol.
K. W. Miller
,
C. S. Yang
Archives of Biochemistry and Biophysics
1984
Corpus ID: 2158573
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE