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Cytochrome P-450 CYP2E1

Known as: Cytochrome P 450 IIE1, N Nitrosodimethylamine Demethylase, CYP2E1 
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include… 
National Institutes of Health

Related topics

Related topics

27 relations
4-nitrophenol 2-monooxygenase activityAromataseCYP2C18 protein, humanCYP2C19 gene

Broader (5)

Aryl Hydrocarbon HydroxylasesCytochrome P450Mixed Function OxygenasesOxidoreductases, N-Demethylating

Narrower (1)

Cytochrome P450 2E1, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation.
Review
2006
Review
2006
Genetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility.
There is increasing evidence identifying the crucial role of numerous dietary components in modifying the process of… 
Review
2005
Review
2005
Alcohol and liver cancer.
Highly Cited
2003
Highly Cited
2003
Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice.
Highly Cited
2002
Highly Cited
2002
Red meat intake, CYP2E1 genetic polymorphisms, and colorectal cancer risk.
N-Nitroso compounds are suspected colorectal cancer (CRC) carcinogens to which individuals on a diet high in red meat (RM) may be… 
Highly Cited
2001
Highly Cited
2001
Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components.
Highly Cited
2001
Highly Cited
2001
Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.
Earlier studies have shown highly exaggerated mechanism-based liver injury of thioacetamide (TA) in rats following moderate diet… 
Highly Cited
2000
Highly Cited
2000
Interindividual variance of cytochrome P450 forms in human hepatic microsomes: correlation of individual forms with xenobiotic metabolism and implications in risk assessment.
Differences in biotransformation activities may alter the bioavailability or efficacy of drugs, provide protection from certain… 
Highly Cited
1994
Highly Cited
1994
Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: possible relevance to low smoking exposure.
Polymorphic metabolism of certain chemical carcinogens may result in differences in susceptibility to cancers. Human CYP2E1… 
Review
1993
Review
1993
Nutrition in the pathogenesis of alcoholic liver disease.
The data and experimental results reviewed here allow the construction of the following hypothesis: alcohol-induced liver disease… 
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