Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

4-nitrophenol 2-monooxygenase activity

Known as: 4-nitrophenol hydroxylase activity, 4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating), 4-nitrophenol-2-hydroxylase activity 
Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+). [EC:1.14.13.29, RHEA:12571]
National Institutes of Health

Related topics

Related topics

1 relation
Cytochrome P-450 CYP2E1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Heterologous expression of human cytochrome P450 2E1 in HepG2 cell line.
AIM Human cytochrome P-450 2E1 (CYP2E1) takes part in the biotransformation of ethanol, acetone, many small-molecule substrates… Expand
2003
2003
Modulation of rat liver cytochrome P450 by protein restriction assessed by biochemical and bacterial mutagenicity methods [corrected].
Protein restriction (PR) significantly inhibits spontaneous and chemical carcinogenesis. Several factors seem to be involved in… Expand
Highly Cited
2002
Highly Cited
2002
In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs.
The aim of this study was to determine the in vitro and in vivo effects of several prototypical inducers, namely beta… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 4
Highly Cited
1997
Highly Cited
1997
Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects.
Cytochrome P450 2E1 (P450 2E1) is active in both the detoxification and activation of small organic molecules. The effects of 2… Expand
Highly Cited
1997
Highly Cited
1997
Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1.
4-Nitrophenol 2-hydroxylation activity was previously shown to be mainly catalyzed by P450 2E1 in animal species and humans. As… Expand
1997
1997
Selective inhibition and induction of CYP activity discriminates between the isoforms responsible for the activation of butylated hydroxytoluene and naphthalene in mouse lung.
1. Selective induction and inhibition experiments have been used to identify the cytochrome P450 (CYP) isoforms responsible for… Expand
Review
1993
Review
1993
Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer.
Caloric restriction in rodents results in increased longevity and a decreased rate of spontaneous and chemically induced… Expand
1993
1993
Acetone-dependent regulation of cytochromes P4502E1 and P4502B1 in rat nasal mucosa.
The inducibility and molecular regulation of cytochrome P4502E1 (CYP2E1) has been examined in nasal mucosa of rats after acetone… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE