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4-nitrophenol 2-monooxygenase activity

Known as: 4-nitrophenol hydroxylase activity, 4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating), 4-nitrophenol-2-hydroxylase activity 
Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+). [EC:1.14.13.29, RHEA:12571]
National Institutes of Health

Related topics

Related topics

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Cytochrome P-450 CYP2E1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Heterologous expression of human cytochrome P450 2E1 in HepG2 cell line.
AIM Human cytochrome P-450 2E1 (CYP2E1) takes part in the biotransformation of ethanol, acetone, many small-molecule substrates… 
2003
2003
Modulation of rat liver cytochrome P450 by protein restriction assessed by biochemical and bacterial mutagenicity methods [corrected].
Protein restriction (PR) significantly inhibits spontaneous and chemical carcinogenesis. Several factors seem to be involved in… 
Highly Cited
1997
Highly Cited
1997
Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects.
Highly Cited
1997
Highly Cited
1997
Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1.
4-Nitrophenol 2-hydroxylation activity was previously shown to be mainly catalyzed by P450 2E1 in animal species and humans. As… 
1997
1997
Selective inhibition and induction of CYP activity discriminates between the isoforms responsible for the activation of butylated hydroxytoluene and naphthalene in mouse lung.
1. Selective induction and inhibition experiments have been used to identify the cytochrome P450 (CYP) isoforms responsible for… 
Review
1993
Review
1993
Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer.
1993
1993
Acetone-dependent regulation of cytochromes P4502E1 and P4502B1 in rat nasal mucosa.
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