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Passage of Inhaled Particles Into the Blood Circulation in Humans
Background—Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are notExpand
Sustained translational repression by eIF2α-P mediates prion neurodegeneration
The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer’s, Parkinson’s and prion diseases, are associated with theExpand
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistanceExpand
Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice
Epidermal development requires the transcription factor p63, as p63−/− mice are born dead, without skin. The gene expresses two proteins, one with an amino-terminal transactivation domain (TAp63) andExpand
HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species
Voltage-gated proton currents regulate generation of reactive oxygen species (ROS) in phagocytic cells. In B cells, stimulation of the B cell antigen receptor (BCR) results in the production of ROSExpand
Neuropathy Target Esterase and Its Yeast Homologue Degrade Phosphatidylcholine to Glycerophosphocholine in Living Cells*
Eukaryotic cells control the levels of their major membrane lipid, phosphatidylcholine (PtdCho), by balancing synthesis with degradation via deacylation to glycerophosphocholine (GroPCho). Here weExpand
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration
In the healthy adult brain synapses are continuously remodelled through a process of elimination and formation known as structural plasticity. Reduction in synapse number is a consistent earlyExpand
Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation.
Apoptosis, a major form of cell death, is characterized by chromatin condensation, a reduction in cell volume and endonuclease cleavage of DNA into oligonucleosomal length fragments. The detection ofExpand
Different forms of cell death induced by putative BCL2 inhibitors
Several inhibitors of BCL2 proteins have been identified that induce apoptosis in a variety of tumor cells, indicating their potential in cancer therapy. We investigated the specificity of sixExpand
Diesel Exhaust Particles in Lung Acutely Enhance Experimental Peripheral Thrombosis
Background—Pollution by particulates has consistently been associated with increased cardiovascular morbidity and mortality, but a plausible biological basis for this association is lacking. MethodsExpand