Peroxisome Proliferator-activated Receptors and Hepatic Stellate Cell Activation*
- T. Miyahara, L. Schrum, H. Tsukamoto
- Biology, MedicineJournal of Biological Chemistry
- 17 November 2000
It is demonstrated that HSC activation is associated with the reductions in PPARγ expression and PPAR-responsive element binding in vivo and is reversed by the treatment withPPARγ ligands in vitro, which implicate diminished PParγ signaling in molecular mechanisms underlying activation of HSC in liver fibrogenesis and the potential therapeutic value of PPARβ ligands for liver fibrosis.
Alcohol and liver cancer.
- I. McKillop, L. Schrum
- Medicine, BiologyAlcohol
- 1 April 2005
Inhibitory effects of microRNA 19b in hepatic stellate cell‐mediated fibrogenesis
- Ashley M. Lakner, N. Steuerwald, L. Schrum
- Biology, MedicineHepatology
- 1 July 2012
Hepatic stellate cell (HSC) activation is a pivotal event in initiation and progression of hepatic fibrosis and a major contributor to collagen deposition driven by transforming growth factor beta…
Anti-Fas Induces Hepatic Chemokines and Promotes Inflammation by an NF-κB-independent, Caspase-3-dependent Pathway*
- S. Faouzi, Beat E. Burckhardt, J. Maher
- Biology, MedicineJournal of Biological Chemistry
- 28 December 2001
It is shown that anti-Fas antibody not only causes apoptosis of liver cells but also provokes hepatic inflammation, indicating that Fas ligation can induce inflammation in the liver in vivo.
Inhibition of phosphatidylinositol 3‐kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis
- G. Son, I. Hines, J. Lindquist, L. Schrum, R. Rippe
- Biology, MedicineHepatology
- 1 November 2009
Targeting PI3K signaling in HSCs during active fibrogenesis inhibits extracellular matrix deposition, including synthesis of type I collagen, and reduces expression of profibrogenic factors.
NF-kappaB inhibits expression of the alpha1(I) collagen gene.
- R. Rippe, L. Schrum, B. Stefanovic, J. Solís-Herruzo, D. Brenner
- BiologyDNA and Cell Biology
- 1 October 1999
Nuclear run-on assays showed that NF-kappaB p65 inhibited transcription of the endogenous alpha1(I) collagen gene, and coimmunoprecipitation experiments demonstrated that NF and Spl do interact in vivo.
Lon Peptidase 1 (LONP1)-dependent Breakdown of Mitochondrial 5-Aminolevulinic Acid Synthase Protein by Heme in Human Liver Cells*
- Qing-shui Tian, Ting Li, Weihong Hou, Jianyu Zheng, L. Schrum, H. Bonkovsky
- BiologyJournal of Biological Chemistry
- 9 June 2011
The data support the existence of a conserved heme feedback regulatory mechanism that functions on the mature form of ALAS-1 protein through the activity of a mitochondrial proteolytic system.
Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function.
- Yekaterina S. Zinchenko, L. Schrum, M. Clemens, R. Coger
- Biology, MedicineTissue engineering
- 4 May 2006
Results illustrate that micropatterning hepatocytes, in the arrangements of this study, significantly improved hepatocyte function.
The Role of p70S6K in Hepatic Stellate Cell Collagen Gene Expression and Cell Proliferation*
- E. Gäbele, S. Reif, R. Rippe
- BiologyJournal of Biological Chemistry
- 8 April 2005
Together, p70S6K plays a crucial role in HSC proliferation, collagen expression, and cell cycle control, thus representing a potential therapeutic target for liver fibrosis.
Expression of Interleukin-10 by in Vitro and in Vivo Activated Hepatic Stellate Cells*
- Saixi C. Wang, M. Ohata, L. Schrum, R. Rippe, H. Tsukamoto
- Biology, MedicineJournal of Biological Chemistry
- 2 January 1998
It is demonstrated that activation of HSC causes enhanced autocrine expression of IL-10 which possesses a negative autoregulatory effect on HSC collagen production mediated at least in part by α1(I) collagen transcriptional inhibition and stimulation of collagenase expression.
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