Cucurbitacins

Known as: 19-Norlanosta-1,5-diene-3,11,22-trione, 16,24-epoxy-2,25-dihydroxy-9-methyl-, (9beta,10alpha,16alpha,24S)-, Cucurbitacins [Chemical/Ingredient], cucurbitacin 
Triterpenes that derive from LANOSTEROL by a shift of the C19 methyl to the C9 position. They are found in seeds and roots of CUCURBITACEAE and other… (More)
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Cucurbitacin and its derivatives (cucurbitacins) are a class of highly oxidized tetracyclic triterpenoids. They are widely… (More)
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2012
2012
Tumor metastasis is the main cause of cancer-related deaths of patients. Breast cancer is highly malignant with considerable… (More)
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Highly Cited
2009
Highly Cited
2009
Pancreatic cancer is an aggressive malignancy that is generally refractory to chemotherapy, thus posing experimental and clinical… (More)
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Review
2006
Review
2006
Recent evidence indicates a convergence of molecular targets for both prevention and therapy of cancer. Signal-transducer-and… (More)
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Review
2005
Review
2005
The natural cucurbitacins constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity… (More)
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Highly Cited
2005
Highly Cited
2005
Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure-activity… (More)
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Highly Cited
2003
Highly Cited
2003
Constitutively activated, tyrosine-phosphorylated signal transducer and activator of transcription (STAT) 3 plays a pivotal role… (More)
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Highly Cited
1996
Highly Cited
1996
Cucurbitacin E has been identified by an empiric screening strategy as a sterol with potent growth inhibitory activity in vitro… (More)
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1986
1986
The cucurbitacins are oxygenated tetracyclic triterpenoids produced as secondary plant compounds by nearly all genera of… (More)
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1961
1961
The carcinostatic activity of elatericin A, elatericin B, elaterin, elaterin methylether, dihydroelatericin A, and… (More)
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