• Publications
  • Influence
Adjuvant and Haemolytic Activities of 47 Saponins Derived from Medicinal and Food Plants
The results suggest that the adjuvant activity of saponins does not relate with haemolytic activity, and it is considered that not only the functional groups themselves, but the overall conformation harmoniously consisting of such functional groups, affects adjUvant activity. Expand
Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats.
Polyphenolic compounds may be involved in the antiobesity effects of SRHW in rats through inhibition of fat metabolizing enzymes (PL, LPL and GPDH) and enhanced lipolysis and inhibited hormone-sensitive lipase activity in rat adipose tissue. Expand
Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities.
Various flavonoids with strong AGEs formation inhibitory activity tended to exhibit strong scavenging activity for 1,1-diphenyl-2-picrylhydrazyl and superoxide anion radicals, with several exceptions. Expand
Antihyperglycemic Effects of Gymnemic Acid IV, a Compound Derived from Gymnema sylvestre Leaves in Streptozotocin-Diabetic Mice
Results indicate that insulin-releasing action of gymnemic acid IV may contribute to the antihyperglycemic effect by the leaves of G. sylvestre, which may be an anti-obese and anti hyperglycemic pro-drug. Expand
Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity.
The methanolic extracts of several natural medicines and medicinal foodstuffs were found to show an inhibitory effect on rat lens aldose reductase, and various flavonoids and related compounds were examined to clarify the structural requirements of flavonoidal activity. Expand
Carnosic acid, a new class of lipid absorption inhibitor from sage.
Carnosic acid significantly inhibited triglyceride elevation in olive oil-loaded mice at doses of 5-20 mg/kg (p.o.) and reduced the gain of body weight and the accumulation of epididymal fat weight in high fat diet-fed mice after 14 days. Expand
Antidiabetic principles of natural medicines. V. Aldose reductase inhibitors from Myrcia multiflora DC. (2): Structures of myrciacitrins III, IV, and V.
Three new flavanone glucosides, myrciacitrins III, IV, and V, were isolated from the leaves of Brazilian Myrcia multiflora and were found to show potent inhibitory activity on aldose reductase. Expand
Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside.
Results indicate the importance of both kaempferol 3-O-beta-D-glucopyranoside and p-coumaroyl moieties for anti-obese effects and a single oral administration of trans-tiliroside increased the expression of PPAR-alpha mRNA of liver tissue in mice. Expand
Antidiabetogenic constituents from several natural medicines
In the course of our studies on antidiabetogenic and antidiabetic principles of natural medicines and medicinal foodstuffs, we have isolated salacinol and kotalanol with unique thiosugar sulfoniumExpand
[Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities].
Mangiferin, three catechins, and two catechin dimers were isolated from the roots of Salacia reticulata and their inhibitory activities against several carbohydrate metabolize enzymes were examined, finding them to inhibit sucrase, isomaltase, and aldose reductase from rat. Expand