• Publications
  • Influence
Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats.
Salacia (S.) reticulata, a Hippocrateaceae plant distributed in Sri Lankan and Indian forests, has been used as a supplementary food in Japan to prevent obesity and diabetes. We examined theExpand
Adjuvant and Haemolytic Activities of 47 Saponins Derived from Medicinal and Food Plants
Abstract Adjuvant and haemolytic activities of 47 saponins purified from medicinal and food plants were examined. The compounds showed various levels of both adjuvant and haemolytic activities.Expand
Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities.
To clarify the structural requirements of flavonoids for formation of advanced glycation end-products (AGEs), various flavonoids were examined. The results suggested the following structuralExpand
Antihyperglycemic Effects of Gymnemic Acid IV, a Compound Derived from Gymnema sylvestre Leaves in Streptozotocin-Diabetic Mice
Abstract We investigated the antihyperglycemic action of a crude saponin fraction and five triterpene glycosides (gymnemic acids I–IV and gymnemasaponin V) derived from the methanol extract of leavesExpand
Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity.
The methanolic extracts of several natural medicines and medicinal foodstuffs were found to show an inhibitory effect on rat lens aldose reductase. In most cases, flavonoids were isolated as theExpand
Carnosic acid, a new class of lipid absorption inhibitor from sage.
The methanolic extract from the leaves of Salvia officinalis L. (sage) showed significant inhibitory effect on serum triglyceride elevation in olive oil-loaded mice (500 and 1000 mg/kg, p.o.) andExpand
Antidiabetic principles of natural medicines. V. Aldose reductase inhibitors from Myrcia multiflora DC. (2): Structures of myrciacitrins III, IV, and V.
Following the characterization of myrciacitrins I and II and myrciaphenones A and B, three new flavanone glucosides, myrciacitrins III, IV, and V, were isolated from the leaves of Brazilian MyrciaExpand
Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside.
The 80% aqueous acetone extracts from the fruit (50 mg/kg/d) and seeds (12.5 and 25 mg/kg/d) of Rosa canina L., but not from the pericarps, were found to show substantial inhibitory effect on theExpand
Antidiabetogenic constituents from several natural medicines
In the course of our studies on antidiabetogenic and antidiabetic principles of natural medicines and medicinal foodstuffs, we have isolated salacinol and kotalanol with unique thiosugar sulfoniumExpand
[Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities].
Mangiferin, three catechins, and two catechin dimers were isolated from the roots of Salacia reticulata (SRE), and examined their inhibitory activities against several carbohydrate metabolize enzymesExpand