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Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.
TLDR
Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities and substitution in the A and C rings has been shown to modify the bioactivity of the compounds. Expand
Antimycobacterial activity and cytotoxicity of flavonoids from the flowers ofChromolaena odorata
TLDR
From the flowers ofChromolaena odorata four flavanones, isosakuranetin, persicogenin, 5,3′-dihydroxy-7,4′-dimethoxyflavanone, 4′-hydroxy-5,6,7,5′,6′-tetramethoxychalcone, and two flavones, acacetin and luteolin were isolated and identified. Expand
Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana.
TLDR
Investigation of the MeOH extract obtained from the root of the Ziziphus mauritiana grown in Thailand resulted in the isolation of two 14- and 13-membered cyclic alkaloids, which exhibited potent antiplasmodial activity against the parasite Plasmodium falciparum. Expand
Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana.
TLDR
Among the isolates, alpha-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells, an activity greater than that of the standard drug ellipticine (IC50 = 1.46 microg/ml), while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values. Expand
Biological Activities of the Chemical Constituents ofErythrina stricta andErythrina subumbrans
Phytochemical investigation of the hexane and CH2Cl2 extracts ofErythrina stricta roots andE. subumbrans stems led to the isolation of six pterocarpans, one flavanone, one isoflavone, two alkaloids,Expand
Chemical constituents and bioactivity of Piper sarmentosum.
TLDR
The results showed that compounds 4 and 6 exhibited both activities while compounds 1, 2, 5, 8 and 11 showed only antituberculosis activity, the first report of the antituber tuberculosis and antiplasmodial activities for these compounds. Expand
Bioactive flavonoids of the flowers of Butea monosperma.
TLDR
One new dihydrochalcone, dihydromonospermoside (7), was isolated from the flowers of Butea monosperma together with three known chalcones and four flavanones, which exhibited varying antimycobacterial activity. Expand
The metabolism of 20-hydroxyecdysone in mice: Relevance to pharmacological effects and gene switch applications of ecdysteroids
TLDR
A novel major metabolite has been identified as 2β,3β,6α,22R,25-pentahydroxy-5β-cholest-8(14)-ene, and the formation of this and the other major metabolites is discussed in relation to the various effects of ecdysteroids already demonstrated on vertebrates. Expand
Antibacterial pterocarpans from Erythrina subumbrans.
TLDR
Interestingly, compounds 2, 4, 5 and 7 were more active against several strains of Streptococcus and Staphylococcus than the standard antibiotics vancomycin and oxacillin, and showed the highest level of activity against all VRSA strains tested, which were resistant to both antibiotics. Expand
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
TLDR
Curcuminoids carrying a conjugated keto (enone) motif, including 40, were significantly more active against T. b. Expand
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