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Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.
TLDR
Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities and substitution in the A and C rings has been shown to modify the bioactivity of the compounds.
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Antimycobacterial activity and cytotoxicity of flavonoids from the flowers ofChromolaena odorata
TLDR
From the flowers ofChromolaena odorata four flavanones, isosakuranetin, persicogenin, 5,3′-dihydroxy-7,4′-dimethoxyflavanone, 4′-hydroxy-5,6,7,5′,6′-tetramethoxychalcone, and two flavones, acacetin and luteolin were isolated and identified.
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Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana.
TLDR
Among the isolates, alpha-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells, an activity greater than that of the standard drug ellipticine (IC50 = 1.46 microg/ml), while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values.
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Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana.
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Biological Activities of the Chemical Constituents ofErythrina stricta andErythrina subumbrans
Phytochemical investigation of the hexane and CH2Cl2 extracts ofErythrina stricta roots andE. subumbrans stems led to the isolation of six pterocarpans, one flavanone, one isoflavone, two alkaloids,…
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Bioactive flavonoids of the flowers of Butea monosperma.
TLDR
One new dihydrochalcone, dihydromonospermoside (7), was isolated from the flowers of Butea monosperma together with three known chalcones and four flavanones, which exhibited varying antimycobacterial activity.
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Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids.
TLDR
The results indicated that modification of the parent structures of betulinic acid, oleanolic acid and ursolic acid to the p-coumarate and, in the case of the latter two triterpenes, the ferulate ester analogues resulted in high antimycobacterial activity.
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Stereochemical evaluation of sesquiterpene quinones from two sponges of the genus Dactylospongia and the implication for enantioselective processes in marine terpene biosynthesis
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Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity.
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Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
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