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Carisbamate

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Hippocampal Proteome of Rats Subjected to the Li-Pilocarpine Epilepsy Model and the Effect of Carisbamate Treatment
In adult rats, the administration of lithium–pilocarpine (LiPilo) reproduces most clinical and neuropathological features of… 
2015
2015
The anticonvulsant actions of carisbamate associate with alterations in astrocyte glutamine metabolism in the lithium–pilocarpine epilepsy model
As reported previously, in the lithium–pilocarpine model of temporal lobe epilepsy (TLE), carisbamate (CRS) produces strong… 
Review
2012
Review
2012
Novel medication targets for the treatment of alcoholism: preclinical studies.
Alcoholism is a complex heterogeneous disease and a number of neurotransmitter and neuromodulator systems have been implicated in… 
2011
2011
A randomized, double‐blind, placebo‐controlled study of the efficacy, safety, and tolerability of adjunctive carisbamate treatment in patients with partial‐onset seizures
Purpose:  To assess the efficacy, safety, and tolerability of adjunctive carisbamate treatment at 800 mg/day and 1,200 mg/day in… 
2011
2011
Carisbamate has powerful disease-modifying effects in the lithium-pilocarpine model of temporal lobe epilepsy
2009
2009
Investigation of the effects of the novel anticonvulsant compound carisbamate (RWJ‐333369) on rat piriform cortical neurones in vitro
Background and purpose:  Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces… 
2009
2009
Evaluation of Carisbamate for the Treatment of Migraine in a Randomized, Double‐Blind Trial
Objective.— This study explored the dose‐response relationship of carisbamate administered at doses of 100 mg per day, 300 mg per… 
2009
2009
Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol-preferring rats.
BACKGROUND Since 1994, when naltrexone (Revia) was approved by the FDA for the treatment of alcoholism, only 2 other drugs… 
2008
2008
A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate‐induced epilepsy
Purpose:  Animal models with spontaneous epileptic seizures may be useful in the discovery of new antiepileptic drugs (AEDs). The… 
2008
2008
The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons
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