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Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.
TLDR
The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants. Expand
Guidelines on nicotine dose selection for in vivo research
TLDR
A new, experimentally based compilation of species-specific dose selection for studies on the in vivo effects of nicotine, addressing issues related to genetic background, age, acute vs chronic exposure, route of administration, and behavioral responses is provided. Expand
The toxicology of climate change: environmental contaminants in a warming world.
TLDR
A paramount issue will be to identify species and populations especially vulnerable to climate-pollutant interactions, in the context of the many other physical, chemical, and biological stressors that will be altered with climate change. Expand
Oxidative stress in toxicology: established mammalian and emerging piscine model systems.
TLDR
Piscine models, in addition to traditional mammalian models, may be useful for further understanding the mechanisms underlying the oxidative stress response, as it is becoming apparent that oxidative stress also affects aquatic organisms exposed to environmental pollutants. Expand
Anxiolytic effects of nicotine in zebrafish
TLDR
The anxiolytic effect of nicotine on the novelty-elicited diving response and subsequent habituation in zebrafish suggested that this effect is no longer dependent on continuing activation of nicotinic receptors once invoked. Expand
Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety
TLDR
The zebrafish novel tank diving task can be useful in discriminating anxiolytic drugs of several classes (serotonergic, benzodiazepines and nicotinic) and has been validated with a novel vs. non-novel test tank. Expand
Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization
TLDR
Discovery of the behavioral, pharmacological, and anatomic specificity of Nicotinic effects on learning, memory, and attention not only aids the understanding of nicotinic involvement in the basis of cognitive function, but also helps in the development of novelNicotinic treatments for cognitive dysfunction. Expand
Nicotinic acetylcholine involvement in cognitive function in animals
TLDR
More work needs to be done to develop and determine the efficacy and safety of novel nicotinic ligands for use in the long-term treatment of human cognitive disorders, and the exact anatomical location and the specific receptor subtypes critically involved in nicotine’s effects are needed. Expand
Nicotine effects on adults with attention-deficit/hyperactivity disorder
TLDR
It is concluded that nicotine deserves further clincal trials with ADHD, because the nicotine effect appears not to be merely a relief of withdrawal symptoms. Expand
Developmental Exposure of Rats to Chlorpyrifos Leads to Behavioral Alterations in Adulthood, Involving Serotonergic Mechanisms and Resembling Animal Models of Depression
TLDR
The results indicate that neonatal CPF exposures, classically thought to be subtoxic, produce lasting changes in 5HT-related behaviors that resemble animal models of depression. Expand
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