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Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro.
1. The effects of the novel bradycardic agent 4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride (ZD 7288) (Zeneca) were investigated on the hyperpolarization-activatedExpand
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Pharmacological inhibition of the M‐current
1. The effects of muscarinic agonists, luteinizing hormone‐releasing hormone (LHRH) analogues, uridine triphosphate (UTP) and divalent cations on K+‐currents in voltage‐clamped bullfrog sympatheticExpand
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M‐currents and other potassium currents in bullfrog sympathetic neurones
1. Bullfrog lumbar sympathetic neurones were voltage‐clamped in vitro through twin micro‐electrodes. Four different outward (K+) currents could be identified: (i) a large sustained voltage‐sensitiveExpand
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Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neurones
Many neurones, when depolarized, exhibit two components of outward K+ current—the voltage-sensitive delayed rectifier current originally described in squid axons by Hodgkin and Huxley1, and anExpand
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Calcium‐dependent potassium conductance in guinea‐pig olfactory cortex neurones in vitro.
1. Guinea‐pig olfactory cortex neurones in vitro (23‐25 degrees C) were voltage clamped by means of a single‐micro‐electrode sample‐and‐hold technique. 2. Under current clamp at the resting potentialExpand
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Fast inward‐rectifying current accounts for anomalous rectification in olfactory cortex neurones.
The somatic membrane of guinea‐pig olfactory cortex neurones in vitro (23 degrees C) was voltage clamped by means of a single‐micro‐electrode sample‐and‐hold technique. In most cells theExpand
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Comparison of the antiepileptogenic effects of an early long‐term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy
Purpose:  Epilepsy is a heterogeneous syndrome characterized by recurrent, spontaneous seizures; continuous medication is, therefore, necessary, even after the seizures have long been suppressed withExpand
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Persistent muscarinic excitation in guinea-pig olfactory cortex neurons: Involvement of a slow post-stimulus afterdepolarizing current
The persistent excitatory effects of the muscarinic agonist oxotremorine-M were investigated in guinea-pig olfactory cortex neurons in vitro (28-30 degrees C) using a single-microelectrodeExpand
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Muscarinic receptor activation induces a prolonged post-stimulus afterdepolarization with a conductance decrease in guinea-pig olfactory cortex neurones in vitro
The persistent excitation of guinea-pig olfactory cortical neurones in vitro by the muscarinic agonist oxotremorine-M (OXO-M) was investigated. In OXO-M (10-20 microM), a slowly-decayingExpand
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The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis
Recent evidence suggests that an altered mammalian (mechanistic) target of rapamycin (mTOR) signaling pathway and its pharmacological modulation might be implicated in several neurological diseasesExpand
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