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Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro.
1. The effects of the novel bradycardic agent 4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride (ZD 7288) (Zeneca) were investigated on the hyperpolarization-activated… Expand
Pharmacological inhibition of the M‐current
1. The effects of muscarinic agonists, luteinizing hormone‐releasing hormone (LHRH) analogues, uridine triphosphate (UTP) and divalent cations on K+‐currents in voltage‐clamped bullfrog sympathetic… Expand
M‐currents and other potassium currents in bullfrog sympathetic neurones
1. Bullfrog lumbar sympathetic neurones were voltage‐clamped in vitro through twin micro‐electrodes. Four different outward (K+) currents could be identified: (i) a large sustained voltage‐sensitive… Expand
Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neurones
Many neurones, when depolarized, exhibit two components of outward K+ current—the voltage-sensitive delayed rectifier current originally described in squid axons by Hodgkin and Huxley1, and an… Expand
Calcium‐dependent potassium conductance in guinea‐pig olfactory cortex neurones in vitro.
1. Guinea‐pig olfactory cortex neurones in vitro (23‐25 degrees C) were voltage clamped by means of a single‐micro‐electrode sample‐and‐hold technique. 2. Under current clamp at the resting potential… Expand
Fast inward‐rectifying current accounts for anomalous rectification in olfactory cortex neurones.
The somatic membrane of guinea‐pig olfactory cortex neurones in vitro (23 degrees C) was voltage clamped by means of a single‐micro‐electrode sample‐and‐hold technique. In most cells the… Expand
Comparison of the antiepileptogenic effects of an early long‐term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy
Purpose: Epilepsy is a heterogeneous syndrome characterized by recurrent, spontaneous seizures; continuous medication is, therefore, necessary, even after the seizures have long been suppressed with… Expand
Persistent muscarinic excitation in guinea-pig olfactory cortex neurons: Involvement of a slow post-stimulus afterdepolarizing current
The persistent excitatory effects of the muscarinic agonist oxotremorine-M were investigated in guinea-pig olfactory cortex neurons in vitro (28-30 degrees C) using a single-microelectrode… Expand
Muscarinic receptor activation induces a prolonged post-stimulus afterdepolarization with a conductance decrease in guinea-pig olfactory cortex neurones in vitro
The persistent excitation of guinea-pig olfactory cortical neurones in vitro by the muscarinic agonist oxotremorine-M (OXO-M) was investigated. In OXO-M (10-20 microM), a slowly-decaying… Expand
The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis
Recent evidence suggests that an altered mammalian (mechanistic) target of rapamycin (mTOR) signaling pathway and its pharmacological modulation might be implicated in several neurological diseases… Expand