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The orexin system regulates alcohol‐seeking in rats
Re‐exposure of cues previously associated with alcohol availability is sufficient and adequate to activate orexin‐containing neurons and drive reinstatement of alcohol‐seeking in alcohol‐preferring rats. Expand
Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies
The evidence that impulsivity is associated with addiction vulnerability is reviewed by considering three lines of evidence: studies of groups at high-risk for development of SUDs; studies of pathological gamblers, where the harmful consequences of the addiction on brain structure are minimised, and genetic association studies linking impulsivity to genetic risk factors for addiction. Expand
Gambling Near-Misses Enhance Motivation to Gamble and Recruit Win-Related Brain Circuitry
It is indicated that near-misses invigorate gambling through the anomalous recruitment of reward circuitry, despite the objective lack of monetary reinforcement on these trials. Expand
Impulsivity and response inhibition in alcohol dependence and problem gambling
Inhibitory control is impaired in alcohol dependence but occurs in the context of psychomotor slowing, and alcohol-dependent individuals failed to show behavioral adjustment following failed stops, which may represent direct effects of chronic alcohol administration on fronto-striatal circuitry. Expand
Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals
The problem gamblers and alcohol-dependent groups displayed impairments in risky decision-making and cognitive impulsivity relative to controls, and shared deficits in tasks linked to ventral prefrontal cortical dysfunction. Expand
Increased Anxiety 3 Months after Brief Exposure to MDMA (‘Ecstasy’) in Rats: Association with Altered 5-HT Transporter and Receptor Density
Interestingly, long-term 5-HT depletion may not be necessary to produce lasting effects on anxiety-like behavior after low-dose MDMA, suggesting that even brief, relatively low- dose MDMA exposure can produce significant,Long-term changes in5-HT receptor and transporter function and associated emotional behavior. Expand
Comparative study on the distribution patterns of P2X1–P2X6 receptor immunoreactivity in the brainstem of the rat and the common marmoset (Callithrix jacchus): Association with catecholamine cell
Findings support a role for extracellular adenosine 5′‐triphosphate in fast synaptic neurotransmission within the brainstem in the rat hindbrain and common marmoset hindbrain. Expand
Neurochemical modulation of cardiovascular control in the nucleus tractus solitarius
This review will attempt to collate the current knowledge regarding the roles of neuromodulators in the NTS, the receptor types involved in mediating observed responses and the degree of importance of such neurochemicals in the tonic regulation of the cardiovascular system. Expand
The GABAB receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats
Abstract GABA systems have been implicated as targets for ethanol at the cellular, molecular and behavioural level. The present study was designed to further examine the potential of the GABABExpand
The orexin1 receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats
Findings for the first time implicate a role for orexins in the motivation to self-administer alcohol and suggest that this may occur independent of any generalized effect on appetitive drive. Expand