Evaluation of Carisbamate for the Treatment of Migraine in a Randomized, Double‐Blind Trial

@article{Cady2009EvaluationOC,
  title={Evaluation of Carisbamate for the Treatment of Migraine in a Randomized, Double‐Blind Trial},
  author={Roger K. Cady and Ninan T. Mathew and Hans Christoph Diener and Peter Hu and Magali Haas and Gerald P. Novak},
  journal={Headache: The Journal of Head and Face Pain},
  year={2009},
  volume={49}
}
Objective.— This study explored the dose‐response relationship of carisbamate administered at doses of 100 mg per day, 300 mg per day, or 600 mg per day, in the prevention of migraine. 

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References

SHOWING 1-10 OF 25 REFERENCES

Prophylaxis of Migraine with Oral Magnesium: Results From A Prospective, Multi-Center, Placebo-Controlled and Double-Blind Randomized Study

TLDR
High-dose oral magnesium appears to be effective in migraine prophylaxis and duration and intensity of attacks and the drug consumption per attack tended to decrease compared to placebo but failed to be significant.

Topiramate in migraine prophylaxis--results from a placebo-controlled trial with propranolol as an active control.

TLDR
It is demonstrated that TPM 100 mg/d is effective in migraine prophylaxis and was better tolerated than TPM 200mg/d, and was generally comparable to PROP.

Cyclandelate in the Prophylaxis of Migraine: A Placebo-Controlled Study

TLDR
The prophylactic action of cyclandelate was investigated in a multicentre, randomized, placebo-controlled, parallel group study and it was not superior to placebo in the Prophylaxis of migraine with regard to parameters usually used in migraine proPHylaxis trials.

Prophylactic Treatment of Migraine with Bisoprolol

TLDR
Treatment with bisoprolol 5 mg resulted in a significant reduction in the frequency of migraine attacks compared to placebo treatment and treatment had no effect on the duration and severity of the attacks.

Topiramate in migraine prophylaxis

TLDR
It is demonstrated that TPM 100 mg/d is effective in migraine prophylaxis and was better tolerated than TPM 200mg/d, and was generally comparable to PROP.

Patterns of Diagnosis and Acute and Preventive Treatment for Migraine in the United States: Results from the American Migraine Prevalence and Prevention Study

TLDR
The patterns of medical treatment for migraineurs in the United States are described to describe the patterns of treatment in the country.

Topiramate for migraine prevention: a randomized controlled trial.

TLDR
Topiramate showed significant efficacy in migraine prevention within the first month of treatment, an effect maintained for the duration of the double-blind phase.

Randomized, controlled, dose-ranging trial of carisbamate for partial-onset seizures

TLDR
Carisbamate at doses of 300, 800, and 1,600 mg/d was effective as adjunctive therapy for reducing the frequency of partial-onset seizures.

Migraine prophylaxis with divalproex.

TLDR
Divalproex is an effective prophylactic drug for patients with migraine headaches and is generally well tolerated.