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Calcineurin

Known as: Protein Phosphatase-2B, Protein Phosphatase 2B, Calcineurin [Chemical/Ingredient] 
Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of… Expand
National Institutes of Health

Related topics

Related topics

26 relations
BrainCalcineurin activityDephosphorylationIn Blood
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Narrower (9)

Cabin1 protein, mouseCalcineurin ACalcineurin BPBO-1 protein, C elegans
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Broader (2)

Calmodulin-Binding ProteinsPhosphoric Monoester Hydrolases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges
Tissue engineering is a promising approach to repair tendon and muscle when natural healing fails. Biohybrid constructs obtained… Expand
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Review
2018
Review
2018
The effects of obesity on skeletal muscle contractile function
ABSTRACT Obesity can cause a decline in contractile function of skeletal muscle, thereby reducing mobility and promoting obesity… Expand
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Highly Cited
2008
Highly Cited
2008
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
Changes in mitochondrial morphology that occur during cell cycle, differentiation, and death are tightly regulated by the balance… Expand
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Highly Cited
1999
Highly Cited
1999
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
The Ca2+-activated protein phosphatase calcineurin induces apoptosis, but the mechanism is unknown. Calcineurin was found to… Expand
Highly Cited
1998
Highly Cited
1998
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic response characterized by increased… Expand
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Highly Cited
1998
Highly Cited
1998
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.
Slow- and fast-twitch myofibers of adult skeletal muscles express unique sets of muscle-specific genes, and these distinctive… Expand
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Review
1998
Review
1998
Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin*
The role of protein phosphatases in the regulation of cellular processes is now well established (1, 2). Calcineurin (also called… Expand
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Highly Cited
1995
Highly Cited
1995
Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex
CALCINEURIN (CaN) is a calcium- and ca 1modulin-dependent protein serine/threonine phosphatase which is critical for several… Expand
Highly Cited
1995
Highly Cited
1995
X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B, FKBP12, and the immunosuppressant drug… Expand
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Highly Cited
1991
Highly Cited
1991
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their… Expand
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