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Calcineurin

Known as: Protein Phosphatase-2B, Protein Phosphatase 2B, Calcineurin [Chemical/Ingredient] 
Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of… 
National Institutes of Health

Related topics

Related topics

26 relations
BrainCalcineurin activityDephosphorylationIn Blood

Narrower (9)

Cabin1 protein, mouseCalcineurin ACalcineurin BPBO-1 protein, C elegans

Broader (2)

Calmodulin-Binding ProteinsPhosphoric Monoester Hydrolases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Involvement of Calcineurin in Transforming Growth Factor-β-mediated Regulation of Extracellular Matrix Accumulation*
Calcineurin is a calcium-dependent, serine/threonine phosphatase that functions as a signaling intermediate. In this study, we… 
Highly Cited
2003
Highly Cited
2003
Regulation of AMPA receptor dephosphorylation by glutamate receptor agonists
Highly Cited
2002
Highly Cited
2002
Evidence for calcineurin-mediated regulation of SERCA 2a activity in human myocardium.
Compromised SERCA 2a activity is a key malfunction leading to the Ca(2+) cycling alterations in failing human myocardium. SERCA… 
Highly Cited
2000
Highly Cited
2000
Pharmacokinetic validation of neoral absorption profiling.
Highly Cited
2000
Highly Cited
2000
Thapsigargin induces a calmodulin/calcineurin‐dependent apoptotic cascade responsible for the death of prostatic cancer cells
New agents are required for the treatment of androgen‐independent prostate cancer. Due to the low rate of proliferation of these… 
Highly Cited
1995
Highly Cited
1995
Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders
1. Introduction.- 2. Structures of EF-Hand Ca2+-Binding Proteins and Annexins.- 3. Gene Structures and Chromosomal Assignments of… 
Highly Cited
1989
Highly Cited
1989
Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.
Two types (I and II) of cDNAs encoding the large (A) subunit of calcineurin, a calmodulin-regulated protein phosphatase, were… 
Highly Cited
1989
Highly Cited
1989
The effects of deletions in the central helix of calmodulin on enzyme activation and peptide binding.
Highly Cited
1984
Highly Cited
1984
Agonist and antagonist properties of calmodulin fragments.
Highly Cited
1983
Highly Cited
1983
Use of calmodulin affinity chromatography for purification of specific calmodulin-dependent enzymes.
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