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Calcineurin

Known as: Protein Phosphatase-2B, Protein Phosphatase 2B, Calcineurin [Chemical/Ingredient] 
Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of… 
National Institutes of Health

Related topics

Related topics

26 relations
BrainCalcineurin activityDephosphorylationIn Blood

Narrower (9)

Cabin1 protein, mouseCalcineurin ACalcineurin BPBO-1 protein, C elegans

Broader (2)

Calmodulin-Binding ProteinsPhosphoric Monoester Hydrolases

Papers overview

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Highly Cited
2008
Highly Cited
2008
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
Changes in mitochondrial morphology that occur during cell cycle, differentiation, and death are tightly regulated by the balance… 
Review
2003
Review
2003
Transcriptional regulation by calcium, calcineurin, and NFAT.
The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family (Chytil and… 
Review
2000
Review
2000
Calcineurin: form and function.
Calcineurin is a eukaryotic Ca(2+)- and calmodulin-dependent serine/threonine protein phosphatase. It is a heterodimeric protein… 
Highly Cited
1999
Highly Cited
1999
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
The Ca2+-activated protein phosphatase calcineurin induces apoptosis, but the mechanism is unknown. Calcineurin was found to… 
Highly Cited
1998
Highly Cited
1998
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.
Slow- and fast-twitch myofibers of adult skeletal muscles express unique sets of muscle-specific genes, and these distinctive… 
Highly Cited
1998
Highly Cited
1998
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Review
1998
Review
1998
Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin*
The role of protein phosphatases in the regulation of cellular processes is now well established (1, 2). Calcineurin (also called… 
Highly Cited
1995
Highly Cited
1995
Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex
CALCINEURIN (CaN) is a calcium- and ca 1modulin-dependent protein serine/threonine phosphatase which is critical for several… 
Review
1992
Review
1992
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
THE immunosuppressive drugs cyclosporin A (CsA) and FKS06 both interfere with a Ca2+-sensitive T-cell signal transduction… 
Highly Cited
1991
Highly Cited
1991
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
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