FAQ

Calcineurin

Known as: Protein Phosphatase-2B, Protein Phosphatase 2B, Calcineurin [Chemical/Ingredient] 
Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2017
05010019792017

Related topics

Related topics

23 relations
BrainCalcineurin activityDephosphorylationIn Blood
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Narrower (4)

Calcineurin ACalcineurin BPPP3CA protein, humanPPP3CC protein, human

Broader (2)

Calmodulin-Binding ProteinsPhosphoric Monoester Hydrolases

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Calcineurin
Signal Transduction
physiological aspects
Brain
Phosphoric Monoester Hydrolases
Protein phosphatase

Papers overview

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Highly Cited
2008
Highly Cited
2008
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.
Changes in mitochondrial morphology that occur during cell cycle, differentiation, and death are tightly regulated by the balance… (More)
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Highly Cited
2004
Highly Cited
2004
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
Sustained calcium signaling induces a state of anergy or antigen unresponsiveness in T cells, mediated through calcineurin and… (More)
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Highly Cited
2003
Highly Cited
2003
Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence.
The azole antifungal fluconazole possesses only fungistatic activity in Candida albicans and, therefore, this human pathogen is… (More)
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Highly Cited
2000
Highly Cited
2000
Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo.
Adult skeletal muscle fibers can be categorized into fast and slow twitch subtypes based on specialized contractile and metabolic… (More)
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Highly Cited
1999
Highly Cited
1999
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
The Ca2+-activated protein phosphatase calcineurin induces apoptosis, but the mechanism is unknown. Calcineurin was found to… (More)
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Highly Cited
1999
Highly Cited
1999
Calcineurin is required for skeletal muscle hypertrophy.
Molecular signaling pathways linking increases in skeletal muscle usage to alterations in muscle size have not been identified… (More)
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Highly Cited
1997
Highly Cited
1997
Calcineurin is required for virulence of Cryptococcus neoformans.
Cyclosporin A (CsA) and FK506 are antimicrobial, immunosuppressive natural products that inhibit signal transduction. In T cells… (More)
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Highly Cited
1997
Highly Cited
1997
Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast.
Calcineurin is a conserved Ca2+/calmodulin-dependent protein phosphatase that plays a critical role in Ca2+ signaling. We… (More)
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Highly Cited
1992
Highly Cited
1992
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin.
Antigen recognition by the T-cell receptor (TCR) initiates events including lymphokine gene transcription, particularly… (More)
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Highly Cited
1979
Highly Cited
1979
Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.
The inhibitory protein that binds calmodulin and thus prevents activation of several Ca2+-dependent enzymes by calmodulin is… (More)
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