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Calcineurin

Known as: Protein Phosphatase-2B, Protein Phosphatase 2B, Calcineurin [Chemical/Ingredient] 
Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of… Expand
National Institutes of Health

Related topics

Related topics

26 relations
BrainCalcineurin activityDephosphorylationIn Blood
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Narrower (9)

Cabin1 protein, mouseCalcineurin ACalcineurin BPBO-1 protein, C elegans
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Broader (2)

Calmodulin-Binding ProteinsPhosphoric Monoester Hydrolases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Regulation of calcium and magnesium homeostasis in plants: from transporters to signaling network.
Calcium (Ca2+) and magnesium (Mg2+) are the most abundant divalent cations in plants. As a nutrient and a signaling ion, Ca2… Expand
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Review
2017
Review
2017
Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?
Alzheimer's disease (AD) is the disease of lost memories. Synaptic loss is a major reason for memory defects in AD. Signaling… Expand
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Highly Cited
2015
Highly Cited
2015
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB
The view of the lysosome as the terminal end of cellular catabolic pathways has been challenged by recent studies showing a… Expand
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Highly Cited
2008
Highly Cited
2008
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.
Changes in mitochondrial morphology that occur during cell cycle, differentiation, and death are tightly regulated by the balance… Expand
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Highly Cited
2004
Highly Cited
2004
Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy.
Calcineurin (PP2B) is a calcium/calmodulin-activated, serine-threonine phosphatase that transmits signals to the nucleus through… Expand
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Highly Cited
1999
Highly Cited
1999
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
The Ca2+-activated protein phosphatase calcineurin induces apoptosis, but the mechanism is unknown. Calcineurin was found to… Expand
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Highly Cited
1998
Highly Cited
1998
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic response characterized by increased… Expand
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Highly Cited
1998
Highly Cited
1998
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.
Slow- and fast-twitch myofibers of adult skeletal muscles express unique sets of muscle-specific genes, and these distinctive… Expand
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Review
1998
Review
1998
Regulation of the calmodulin-stimulated protein phosphatase, calcineurin.
The role of protein phosphatases in the regulation of cellular processes is now well established (1, 2). Calcineurin (also called… Expand
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Highly Cited
1991
Highly Cited
1991
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their… Expand
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