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Calcineurin

Known as: Protein Phosphatase-2B, Protein Phosphatase 2B, Calcineurin [Chemical/Ingredient] 
Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of… 
National Institutes of Health

Related topics

Related topics

26 relations
BrainCalcineurin activityDephosphorylationIn Blood

Narrower (9)

Cabin1 protein, mouseCalcineurin ACalcineurin BPBO-1 protein, C elegans

Broader (2)

Calmodulin-Binding ProteinsPhosphoric Monoester Hydrolases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice.
Highly Cited
2000
Highly Cited
2000
Thapsigargin induces a calmodulin/calcineurin‐dependent apoptotic cascade responsible for the death of prostatic cancer cells
New agents are required for the treatment of androgen‐independent prostate cancer. Due to the low rate of proliferation of these… 
Highly Cited
2000
Highly Cited
2000
Pharmacokinetic validation of neoral absorption profiling.
Highly Cited
1997
Highly Cited
1997
Shaping of IPSCs by Endogenous Calcineurin Activity
Synaptic inhibition, mediated by GABAA receptors, regulates neuronal firing, influences coincidence detection (König et al… 
Highly Cited
1995
Highly Cited
1995
Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders
1. Introduction.- 2. Structures of EF-Hand Ca2+-Binding Proteins and Annexins.- 3. Gene Structures and Chromosomal Assignments of… 
Highly Cited
1993
Highly Cited
1993
p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells
In T lymphocytes, triggering of the T cell receptor (TCR) induces several signaling cascades which ultimately synergize to induce… 
Highly Cited
1992
Highly Cited
1992
Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast
THE structurally unrelated immunosuppressants FK506 and cyclosporin A (CsA) act similarly, inhibiting a Ca2+-dependent signal… 
Highly Cited
1989
Highly Cited
1989
Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.
Two types (I and II) of cDNAs encoding the large (A) subunit of calcineurin, a calmodulin-regulated protein phosphatase, were… 
Highly Cited
1987
Highly Cited
1987
Cyclic-AMP-dependent phosphorylation of voltage-sensitive sodium channels in primary cultures of rat brain neurons.
Highly Cited
1984
Highly Cited
1984
Agonist and antagonist properties of calmodulin fragments.
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