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CTLA4 protein, human

Known as: cytotoxic T-lymphocyte-associated protein 4, human, Cytotoxic T-Lymphocyte-Associated Antigen 4, Cytotoxic T-Lymphocyte Protein 4 
Cytotoxic T-lymphocyte protein 4 (223 aa, ~25 kDa) is encoded by the human CTLA4 gene. This protein is involved in the inhibition of T-cell mediated… 
National Institutes of Health

Related topics

Related topics

22 relations
Anti-CTLA-4 Monoclonal Antibody AGEN1884CTLA-4-IgCTLA4 geneCTLA4 wt Allele

Broader (1)

cytotoxic T-lymphocyte antigen 4

Papers overview

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Review
2017
Review
2017
Lessons from CTLA-4 deficiency and checkpoint inhibition.
Highly Cited
2013
Highly Cited
2013
CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE(-/-) mice.
AIMS Cytotoxic T lymphocyte antigen 4 (CTLA4) exerts inhibitory effects on T-cell activation by competition with CD28. In this… 
Highly Cited
2009
Highly Cited
2009
Production and characterization of transgenic pigs expressing porcine CTLA4‐Ig
Phelps CJ, Ball SF, Vaught TD, Vance AM, Mendicino M, Monahan JA, Walters AH, Wells KD, Dandro AS, Ramsoondar JJ, Cooper DKC… 
Highly Cited
2004
Highly Cited
2004
Genetic association of coeliac disease susceptibility to polymorphisms in the ICOS gene on chromosome 2q33
An interesting candidate gene region for coeliac disease (CD), a common multifactorial disease, is a segment on 2q33–37… 
Highly Cited
2002
Highly Cited
2002
Dual Effect of CD85/Leukocyte Ig-Like Receptor-1/Ig-Like Transcript 2 and CD152 (CTLA-4) on Cytokine Production by Antigen-Stimulated Human T Cells1
The functional outcome of a T cell response to Ag is the result of a balance between coactivation and inhibitory signals. In this… 
Highly Cited
2001
Highly Cited
2001
B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.
To examine whether B7 costimulation can be mediated by a molecule on T cells that is neither CD28 nor CTLA4, we generated mice… 
Highly Cited
2001
Highly Cited
2001
Regulation of Surface and Intracellular Expression of CTLA‐4 on Human Peripheral T Cells
Cytotoxic T‐lymphocyte‐associated antigen (CTLA‐4) is an important downregulator of T‐cell activation. In order to analyze the… 
Highly Cited
1999
Highly Cited
1999
The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival.
Blocking the interaction of the CD28 costimulatory receptor with its ligands, CD80 and CD86, inhibits in vivo immune responses… 
Highly Cited
1997
Highly Cited
1997
Antiviral immune responses in CTLA4 transgenic mice
The role of B7 binding CD28 in the regulation of T- and B-cell responses against viral antigens was assessed in transgenic mice… 
Highly Cited
1996
Highly Cited
1996
An Mse I RFLP in the human CTLA4 promotor.
We present a PCR-based Mse I restriction fragment length polymorphism (RFLP) in the promotor of the human CTLA4 gene at position… 
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