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Anti-CTLA-4 Monoclonal Antibody AGEN1884

Known as: AGEN-1884, AGEN1884 
A recombinant human monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with immune… Expand
National Institutes of Health

Papers overview

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2019
2019
BackgroundAngiosarcoma is an uncommon endothelial malignancy and a highly aggressive soft tissue sarcoma. Due to its infiltrative… Expand
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2018
2018
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen… Expand
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2018
2018
3075Background: AGEN1884 is a novel fully human IgG1 monoclonal antibody targeting cytotoxic T lymphocyte-associated protein 4… Expand
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Review
2018
Review
2018
• Antigen-speci c T-cell activation is regulated by a balance of co-stimulatory and co-inhibitory signals, such as those mediated… Expand
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2017
2017
3075Background: AGEN1884 is a fully human IgG1 monoclonal antibody targeting the co-inhibitory protein cytotoxic T lymphocyte… Expand
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2017
2017
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) play important non-redundant… Expand
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2016
2016
CTLA-4 is an important negative regulator of T cell function. Together with CD28, these two co-receptors exemplify a co… Expand
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