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Anti-CTLA-4 Monoclonal Antibody AGEN1884
Known as:
AGEN-1884
, AGEN1884
A recombinant human monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with immune…
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National Institutes of Health
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Related topics
Related topics
2 relations
CTLA4 protein, human
antigen binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody
Randi B Gombos
,
Ana González
,
+24 authors
N. Wilson
PLoS ONE
2018
Corpus ID: 4824675
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen…
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2018
2018
Phase I/II study of CTLA-4 inhibitor AGEN1884 + PD-1 Inhibitor AGEN2034 in patients with advanced/refractory solid tumors, with expansion into 2L cervical cancer and solid tumors.
J. Coward
,
C. Lemech
,
+12 authors
H. Youssoufian
Annals of Oncology
2018
Corpus ID: 81576557
Review
2018
Review
2018
Evaluation of Peripheral T-Cell Subset Proliferation as a Pharmacodynamic Assay to Guide the Development of Anti-CTLA-4 and PD-1 Antibody Combinations in Patients With Solid Tumors
P. DeSouza
,
E. Drouin
2018
Corpus ID: 51777556
• Antigen-speci c T-cell activation is regulated by a balance of co-stimulatory and co-inhibitory signals, such as those mediated…
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2018
2018
Phase I open-label, ascending dose trial of AGEN1884, an anti-CTLA-4 monoclonal antibody, in advanced solid malignancies: Dose selection for combination with PD-1 blockade.
B. Wilky
,
P. Kumthekar
,
+16 authors
R. Stein
2018
Corpus ID: 81419804
3075Background: AGEN1884 is a novel fully human IgG1 monoclonal antibody targeting cytotoxic T lymphocyte-associated protein 4…
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2018
2018
Phase I, open-label ascending dose trial of anti-CTLA-4 monoclonal antibody AGEN1884 in advanced solid malignancies, with expansion to patients refractory to recent anti-PD-1/PD-L1 therapy.
B. Wilky
,
P. Kumthekar
,
+17 authors
H. Youssoufian
Annals of Oncology
2018
Corpus ID: 81670250
2017
2017
Phase 1 open-label, multiple ascending dose trial of AGEN1884, an anti-CTLA-4 monoclonal antibody, in advanced solid malignancies.
B. Wilky
,
P. Kumthekar
,
+11 authors
J. Cuillerot
2017
Corpus ID: 80328802
3075Background: AGEN1884 is a fully human IgG1 monoclonal antibody targeting the co-inhibitory protein cytotoxic T lymphocyte…
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2017
2017
Abstract 3654: AGEN1884, an IgG1 anti-CTLA-4 antibody, combines effectively with PD-1 blockade in primary human T cell assays and in a non-human primate pharmacodynamic (PD) model
E. Drouin
,
D. Savitsky
,
+19 authors
N. Wilson
2017
Corpus ID: 89825813
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) play important non-redundant…
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