Skip to search formSkip to main contentSkip to account menu

CLSPN protein, human

Known as: claspin homolog (Xenopus laevis), human, Claspin, claspin, human 
Claspin (1339 aa, ~151 kDa) is encoded by the human CLSPN gene. This protein is involved in cell cycle arrest in response to errors in DNA… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (1)

Adaptor Proteins, Signal Transducing
CLSPN geneCell Cycle CheckpointsCell Cycle ControlCell Nucleus

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas.
We previously showed that checkpoint kinase 1 (Chk1) and Claspin, two DNA-damage checkpoint proteins, were down-regulated by 1,25… 
Highly Cited
2006
Highly Cited
2006
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.
Highly Cited
2006
Highly Cited
2006
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress.
Highly Cited
2006
Highly Cited
2006
Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery
Highly Cited
2006
Highly Cited
2006
Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling
TopBP1-like proteins, which include Xenopus laevis Xmus101, are required for DNA replication and have been linked to replication… 
Highly Cited
2005
Highly Cited
2005
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.
Cell-cycle checkpoints induced by DNA damage or replication play critical roles in the maintenance of genomic integrity during… 
Highly Cited
2004
Highly Cited
2004
Adaptation of a DNA Replication Checkpoint Response Depends upon Inactivation of Claspin by the Polo-like Kinase
Highly Cited
2004
Highly Cited
2004
ATR, Claspin and the Rad9-Rad1-Hus1 Complex Regulate Chk1 and Cdc25A in the Absence of DNA Damage
The ATR and Chk1 kinases are essential to maintain genomicintegrity. ATR, with Claspin and the Rad9-Rad1-Hus1 complex,activates… 
Highly Cited
2004
Highly Cited
2004
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.
Claspin is a homolog of Mrc1, a checkpoint protein required for the DNA replication checkpoint in yeast. In Xenopus… 
Highly Cited
2004
Highly Cited
2004
Human Claspin Is a Ring-shaped DNA-binding Protein with High Affinity to Branched DNA Structures*
Claspin is an essential protein for the ATR-dependent activation of the DNA replication checkpoint response in Xenopus and human… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)