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CHEK2 gene

Known as: bA444G7, PP1425, CHEK2 
This gene plays a role in cell survival and the negative regulation of cell growth.
National Institutes of Health

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Related topics

13 relations
Brain NeoplasmsCHEK2 protein, humanCell SurvivalColorectal Neoplasms

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CHEK2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
CHEK2 1100delC Is a Susceptibility Allele for HNPCC-Related Colorectal Cancer
Purpose: The pathogenic CHEK2 1100delC variant is firmly established as a breast cancer susceptibility allele. Dutch CHEK2… 
2005
2005
German populations with infrequent CHEK2*1100delC and minor associations with early-onset and familial breast cancer.
2005
2005
Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals
A protein-truncating variant of CHEK2, 1100delC, is associated with a moderate increase in breast cancer risk. We have determined… 
2004
2004
Cds1 Phosphorylation by Rad3-Rad26 Kinase Is Mediated by Forkhead-associated Domain Interaction with Mrc1*
The protein kinase Cds1 is an effector of the replication checkpoint in the fission yeast Schizosaccharomyces pombe. Cds1 is… 
Highly Cited
2003
Highly Cited
2003
The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families.
The frame-shifting mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2) has been reported to be associated with… 
Highly Cited
2003
Highly Cited
2003
FHA Domain-Mediated DNA Checkpoint Regulation of Rad53
Saccharomyces cerevisiae Rad53 is a protein kinase central to the DNA damage and DNA replication checkpoint signaling pathways… 
Highly Cited
2003
Highly Cited
2003
BRCA1, BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer families in South India.
Cancer of the breast is the second most common cancer seen among Indian women. This study describes the use of DHPLC for mutation… 
2003
2003
Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.
2000
2000
Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae.
RAD53 encodes a conserved protein kinase that acts as a central transducer in the DNA damage and the DNA replication checkpoint… 
Highly Cited
1999
Highly Cited
1999
RAD53 regulates DBF4 independently of checkpoint function in Saccharomyces cerevisiae.
The Cdc7p and Dbf4p proteins form an active kinase complex in Saccharomyces cerevisiae that is essential for the initiation of… 
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