CHEK2 gene

Known as: bA444G7, PP1425, CHEK2 
This gene plays a role in cell survival and the negative regulation of cell growth.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
PURPOSE To estimate the risk of breast cancer in a woman who has a CHEK2 mutation depending on her family history of breast… (More)
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Review
2008
Review
2008
PURPOSE CHEK2*1100delC heterozygosity may be associated with an increased risk of breast cancer; however, it is unclear whether… (More)
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Highly Cited
2006
Highly Cited
2006
CONTEXT Genetic testing for inherited mutations in BRCA1 and BRCA2 has become integral to the care of women with a severe family… (More)
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Highly Cited
2005
Highly Cited
2005
The CHEK2 kinase is a tumor suppressor whose activation in response to DNA double-strand breaks contributes to cell cycle arrest… (More)
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Highly Cited
2004
Highly Cited
2004
  • American journal of human genetics
  • 2004
Previous studies of families with multiple cases of breast cancer have indicated that a frameshift alteration in the CHEK2 gene… (More)
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Highly Cited
2004
Highly Cited
2004
To establish the importance of CHEK2 mutations for familial breast cancer incidence in the German population, we have screened… (More)
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Highly Cited
2003
Highly Cited
2003
Recently, variants in CHEK2 gene were shown to associate with sporadic prostate cancer in the USA. In the present study from… (More)
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Highly Cited
2003
Highly Cited
2003
Because of genetic heterogeneity, the identification of breast cancer-susceptibility genes has proven to be exceedingly difficult… (More)
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Highly Cited
2002
Highly Cited
2002
Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer, but account for only a small fraction of breast… (More)
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Highly Cited
1994
Highly Cited
1994
In eukaryotes a cell-cycle control termed a checkpoint causes arrest in the S or G2 phases when chromosomes are incompletely… (More)
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