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CHEK2 gene

Known as: bA444G7, PP1425, CHEK2 
This gene plays a role in cell survival and the negative regulation of cell growth.
National Institutes of Health

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Related topics

13 relations
Brain NeoplasmsCHEK2 protein, humanCell SurvivalColorectal Neoplasms

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CHEK2 wt Allele

Papers overview

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2020
2020
Complete Response to Chemotherapy in Metastatic Pancreatic Carcinoma Associated with Double Heterozygous Germline Mutation in BRCA2 and CHEK2 Genes - a Case Report.
BACKGROUND Metastatic pancreatic carcinoma is an aggressive disease with adverse prognosis. Despite slight advances in… 
2018
2018
Abstract P4-06-03: Characteristics of CHEK2 mutation carriers in a large academic health center in Michigan
Background: Germline mutations in CHEK2 , a cell-cycle checkpoint kinase, are associated with increased susceptibility to breast… 
2015
2015
Novel CHEK2 Mutation Identified Potentially Responsible for Early Onset of Breast Cancers in Chinese Population
Breast cancer is the most frequently diagnosed cancer and the second deadly tumor in females worldwide. On average, breast cancer… 
Review
2015
Review
2015
High frequency of BRCA 1 , but not CHEK 2 or NBS 1 ( NBN ) , founder mutations in Russian ovarian cancer patients
Background: A significant portion of ovarian cancer (OC) cases is caused by germ-line mutations in BRCA1 or BRCA2 genes. BRCA… 
2014
2014
Abstract 942: Imputation from The 1000 Genomes Project identifies rare large effect variants of BRCA2-K3326X and CHEK2-I157T as risk factors for lung cancer; a study from the TRICL consortium
We conducted imputation to The 1000 Genomes Project of genome-wide association studies of lung cancer in populations of European… 
2010
2010
CHEK2 gene mutations, CYP1B1 gene 355T/T polymorphism, and HPV infection approached as urinary bladder cancer predisposing factors.
Introduction. CHEK2 and CYP1B1 are among the genes of which mutations may increase the risk of cancer incidence. A multi-organ… 
2009
2009
CHEK 2 Mutations Affecting Kinase Activity Together With Mutations in TP 53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer
Background: Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used… 
2009
2009
[Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas].
The purpose of this study was to investigate informativety and clinical significance of most frequent somatic alterations in K… 
2006
2006
Genetic and Epigenetic Analysis of CHEK 2 in Sporadic Breast , Colon , and Ovarian Cancers
Purpose: Germ-line variants in CHEK2 have been associated with increased breast, thyroid, prostate, kidney, and colorectal cancer… 
2001
2001
Advances in Brief p 53 , CHK 2 , and CHK 1 Genes in Finnish Families with Li-Fraumeni Syndrome : Further Evidence of CHK 2 in Inherited Cancer Predisposition 1
Germ-line mutations in the p53 gene predispose individuals to LiFraumeni syndrome (LFS). The cell cycle checkpoint kinases CHK1…