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- Publications
- Influence
Genome-wide association study identifies novel breast cancer susceptibility loci
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast… Expand
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
- K. Michailidou, P. Hall, +216 authors D. Easton
- Biology, Medicine
- Nature Genetics
- 1 April 2013
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk… Expand
Association analysis identifies 65 new breast cancer risk loci
- K. Michailidou, S. Lindström, +356 authors D. Easton
- Biology, Medicine
- Nature
- 23 October 2017
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast… Expand
A common coding variant in CASP8 is associated with breast cancer risk
- A. Cox, A. Dunning, +76 authors D. Easton
- Biology, Medicine
- Nature Genetics
- 1 March 2007
The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with… Expand
Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular… Expand
High proportion of BRCA1/2 founder mutations in Hispanic breast/ovarian cancer families from Colombia
- D. Torres, Muhammad Usman Rashid, +7 authors U. Hamann
- Biology, Medicine
- Breast Cancer Research and Treatment
- 15 May 2007
In South America, a high proportion of the population is of Hispanic origin with an important representation in Colombia. Since nothing is known about the contribution of BRCA1 and BRCA2 germline… Expand
Genome-wide association studies identify four ER negative–specific breast cancer risk loci
- M. García-Closas, F. Couch, +267 authors P. Kraft
- Biology, Medicine
- Nature Genetics
- 1 April 2013
Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of… Expand
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were… Expand
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
- S. Bojesen, K. Pooley, +434 authors A. Dunning
- Biology, Medicine
- Nature Genetics
- 1 April 2013
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in… Expand
Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)
- N. Mavaddat, D. Barrowdale, +130 authors A. Antoniou
- Medicine
- Cancer Epidemiology, Biomarkers & Prevention
- 5 December 2011
Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets of mutation carriers should allow further tumor… Expand