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CHEK2 protein, human
Known as:
RAD53 protein, human
, CHEK2
, CHK2 Homolog
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Serine/threonine-protein kinase Chk2 (543 aa, ~61 kDa) is encoded by the human CHEK2 gene. This protein plays an essential role in the DNA damage…
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National Institutes of Health
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Related topics
Related topics
25 relations
ATM Signaling Pathway
Ataxia Telangiectasia Mutated Proteins
Aurora Kinase B
CHEK1 protein, human
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Broader (1)
checkpoint kinase 2
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Novel variants of the DNA damage checkpoint protein Cds1 in Schizosaccharomyces pombe
Jessica Fletcher
2017
Corpus ID: 90776721
In the model organism Schizosaccharomyces pombe, the Cds1 (checking DNA synthesis 1) kinase is activated at the S-phase…
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2014
2014
Structure-based design , discovery and development of checkpoint kinase inhibitors as potential anti-cancer therapies
Thomas P Matthews
,
Alan M. Jones
,
I. Collins
2014
Corpus ID: 51943394
Review
2014
Review
2014
Ataxia-Telangiectasia Mutated Kinase : A Potential New Target for Suppressing In fl ammation in Heart Failure ?
R. Kukreja
2014
Corpus ID: 38633345
A taxia-telangiectasia mutated (ATM) kinase, the mutation of which causes the autosomal recessive disease ataxiatelangiectasia…
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2012
2012
Structural Delineation of MDC 1-FHA Domain Binding with CHK 2-pThr 68
Hsin-Hui Wu
,
Pei-Yu Wu
,
Kai-Fa Huang
,
Y. Kao
,
M. Tsai
2012
Corpus ID: 42598768
Mammalian MDC1 interacts with CHK2 in the regulation of DNA damage-induced S-phase checkpoint and apoptosis, which is directed by…
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Review
2011
Review
2011
CHEK2 (CHK2 checkpoint homolog (S. pombe))
N. Uhrhammer
2011
Corpus ID: 85055060
Review on CHEK2 (CHK2 checkpoint homolog (S. pombe)), with data on DNA, on the protein encoded, and where the gene is implicated.
2009
2009
Abstract #455: Protein phosphatase 2A and CHK2 binding is disrupted by DNA damage
Alyson K. Freeman
,
Virna Dapić
,
A. Monteiro
2009
Corpus ID: 80542116
Maintenance of genomic integrity is an essential part of every cell9s existence. The DNA damage response pathway allows for the…
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2008
2008
Checkpoint Regulation of S-Phase Transcription: A Dissertation
C. Dutta
2008
Corpus ID: 83376549
The DNA replication checkpoint transcriptionally up-regulates genes that allow cells to adapt to and survive replication stress…
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2006
2006
Tumour stem cells: Rooting out resistance
N. McCarthy
Nature Reviews. Cancer
2006
Corpus ID: 30090808
CHK2 http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi?db=gene&c md=Retrieve&dopt=full_ report&list_uids=11200 Glioblastomas are…
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2002
2002
Advances in Brief Regulation of BRCA 1 Phosphorylation by Interaction with Protein Phosphatase 1 1
Y. Liu
,
D. Virshup
,
Raymond L. White
,
L. Hsu
2002
Corpus ID: 33664972
Numerous reports have revealed that the tumor suppressor BRCA1 may play an important role in DNA damage repair. BRCA1 is…
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1998
1998
Kinase humaine de controle, hcds1, compositions et procedes
W. Luyten
,
A. Parker
,
C. Mcgowan
,
A. Blasina
1998
Corpus ID: 90519275
L'invention porte sur un nouveau gene kinase humain de controle, hCDS1, sur une proteine translatee, sur des compositions, des…
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