CHEK2 protein, human

Known as: RAD53 protein, human, CHEK2, CHK2 Homolog 
Serine/threonine-protein kinase Chk2 (543 aa, ~61 kDa) is encoded by the human CHEK2 gene. This protein plays an essential role in the DNA damage… (More)
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Cell cycle checkpoint kinase 2 (CHEK2) is a transducer of cellular responses to DNA damage. The CHEK2 1100delC has previously… (More)
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Highly Cited
2003
Highly Cited
2003
Most human somatic cells can undergo only a limited number of population doublings in vitro. This exhaustion of proliferative… (More)
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Highly Cited
2003
Highly Cited
2003
MRE11, RAD50 and NBS1 form a highly conserved protein complex (the MRE11 complex) that is involved in the detection, signalling… (More)
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Highly Cited
2003
Highly Cited
2003
The replication checkpoint is a dedicated sensor-response system activated by impeded replication forks. It stabilizes stalled… (More)
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Highly Cited
2002
Highly Cited
2002
Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer, but account for only a small fraction of breast… (More)
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Highly Cited
2001
Highly Cited
2001
Chromatid catenation is actively monitored in human cells, with progression from G(2) to mitosis being inhibited when chromatids… (More)
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Highly Cited
2001
Highly Cited
2001
Checkpoint responses change as cells proceed through the cell cycle. Here we describe a novel checkpoint gene in fission yeast… (More)
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Highly Cited
2000
Highly Cited
2000
A checkpoint operating in the G(2) phase of the cell cycle prevents entry into mitosis in the presence of DNA damage. UCN-01, a… (More)
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Highly Cited
2000
Highly Cited
2000
Cds1, a serine/threonine kinase, enforces the S-M checkpoint in the fission yeast Schizosaccharomyces pombe. Cds1 is required for… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND In human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of… (More)
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