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CGS 8216

Known as: CGS-8216 
National Institutes of Health

Papers overview

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2004
2004
The benzodiazepine antagonist CGS 8216 decreases both shocked and unshocked drinking in rats
Previous studies of the benzodiazepine antagonist CGS 8216 have reported that this compound may enhance the punishment-induced… 
1987
1987
Withdrawal syndrome induced by the benzodiazepine receptor antagonist CGS 8216 after chronic diazepam treatment in rats
The high anxiolytic, hypnotic, and sedative potential of the benzodiazepine tranquilizers suggests that mental and physical… 
1987
1987
Characteristics of the abstinence syndrome induced by the administration of the benzodiazepine antagonist CGS 8216 to rats following chronic treatment with diazepam
: Male rats were treated with 5 and 10 mg/kg diazepam once daily for 5-30 days. After the drug discontinuation a benzodiazepine… 
1987
1987
[Characteristics of the abstinence syndrome induced by the administration of the benzodiazepine antagonist CGS 8216 to rats following chronic treatment with diazepam].
Male rats were treated with 5 and 10 mg/kg diazepam once daily for 5-30 days. After the drug discontinuation a benzodiazepine… 
1987
1987
[Antiabstinent action of fenibut and baclofen on a model of abstinence induced by the benzodiazepine receptor antagonist CGS 8216 in rats receiving diazepam].
Benzodiazepine receptor antagonist CGS 8216 (2.5 mg/kg) induced clear-cut signs of abstinence lasting 1-1.5 hours in rats after… 
1987
1987
Antiwithdrawal action of fenibut and baclofen on experimental withdrawal induced by CGS 8216, a benzodiazepine receptor antagonist, in rats receiving diazepam
Vol. I, New York (1985), pp. 163-175. 5. A. Clarke and S. File, Prog. Neuro-Psychopharmacol., 6, 27 (1982), 6. V. S. Fang, B, Y… 
1986
1986
Effect of CGS-8216 on high-dose flurazepam convulsive threshold.
Flurazepam, a clinically proven and widely accepted sedative hypnotic, has been shown by a number of investigators to produce… 
1985
1985
Evidence that a benzodiazepine receptor mechanism regulates the secretion of pituitary beta-endorphin in rats.
The effects of agents representing three classes of benzodiazepine receptor-acting drugs on circulating levels of beta-endorphin… 
1983
1983
3-carboethoxy-beta-carboline (beta-CCE) elicits electroencephalographic seizures in rats: reversal by the benzodiazepine antagonist CGS 8216.
Intravenous administration of 3-carboethoxy-beta-carboline (beta-CCE, 10 mg/kg) to rats resulted in multiple bursts of rhythmic… 
1982
1982
Interaction of the benzodiazepine antagonists, CGS 8216 and Ro 15-1788, with central adenosine A-1 receptors.
Although the potent benzodiazepine antagonist CGS 8216 has in vitro activity indicative of an interaction with central adenosine…