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Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy
TLDR
The amygdala, thalamus, olfactory cortex, hippocampus, neocortex, and substantia nigra are the most sensitive regions to epilepsy‐related damage following convulsions produced by pilocarpine.
Long‐Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures
TLDR
It is demonstrated that structural damage of the brain may lead to spontaneously recurrent convulsions (chronic epilepsy) in rats and that kindling mechanisms underlie the development of epileptic foci from structural brain lesions, which suggests thatkindling mechanisms may be involved in the etiology of some forms of epilepsy in humans.
Rat Brain Slices Produce and Liberate Kynurenic Acid upon Exposure to l‐Kynurenine
TLDR
The processes described here are suggested to underlie the role of KYNA as a neuromodulator and possible endogenous neuroprotective agent and anticonvulsant.
Cholinomimetics produce seizures and brain damage in rats
TLDR
The results suggest that the excessive stimulation of cholinergic muscarinic receptors can lead to limbic seizures and brain damage in rats, and it is postulated that mus carinic cholinerential mechanisms are linked to the etiology of temporal lobe epilepsy and epileptic brain damage.
Sedative and anticonvulsant drugs suppress postnatal neurogenesis
TLDR
Whether sedative and anticonvulsant drugs influence early postnatal neurogenesis in the developing mammalian brain is explored.
AhR and IDO1 in pathogenesis of Covid-19 and the “Systemic AhR Activation Syndrome:” a translational review and therapeutic perspectives
TLDR
It is hypothesize that elimination of factors known to up-regulate AhRs, or implementation of measures known to down- Regulate AhR, should decrease severity of infection.
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