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Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study
Behavioural, electroencephalographic and neuropathological responses to increasing doses of pilocarpine (100-400 mg/kg) administered intraperitoneally to rats were studied. At the dose of 400 mg/kgExpand
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Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy
High‐dose treatment with pilocarpine hydrochloride, a cholinergic muscarinic agonist, induces seizures in rodents following systemic or intracerebral administration. Pilocarpine seizures areExpand
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Long‐Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures
Summary: Structural damage of the human brain (perinatal damage, cerebral trauma, head injury, cerebrovascular and degenerative diseases, intracranial tumor, metabolic diseases, toxins, drug‐inducedExpand
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Seizures produced by pilocarpine in mice: A behavioral, electroencephalographic and morphological analysis
Increasing doses of pilocarpine, 100-400 mg/kg, were given intraperitoneally to mice and the resulting behavioral, electroencephalographic and neuropathological alterations were studied. NoExpand
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Identification and quantification of kynurenic acid in human brain tissue
Serial ion-exchange and high-performance liquid chromatography separations were employed for the tissue extraction and purification of kynurenic acid (KYNA). Subsequently, the compound isolated fromExpand
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Rat Brain Slices Produce and Liberate Kynurenic Acid upon Exposure to l‐Kynurenine
Abstract: The incorporation of l‐kynurenine (L‐KYN) into kynurenic acid (KYNA) was examined in rat brain slices. KYNA was measured in the slices and in the incubation medium after purification byExpand
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The susceptibility of rats to pilocarpine-induced seizures is age-dependent.
Behavioral, electroencephalographic and morphological changes induced by systemic administration of pilocarpine hydrochloride were studied in 3-90-day-old rats. Pilocarpine, 100, 200 and 380 mg/kg,Expand
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Cholinomimetics produce seizures and brain damage in rats
Microinjections of the cholinergic agonists, carbachol and bethanechol, either into the amygdala or into the dorsal hippocampus produced sustained limbic seizures and brain damage in rats. SystemicExpand
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Sedative and anticonvulsant drugs suppress postnatal neurogenesis
Sedative and anticonvulsant drugs, which inhibit N‐methyl‐D‐aspartate receptor–mediated excitation or enhance GABA‐mediated action, may cause apoptotic neurodegeneration in the developing mammalianExpand
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Dopamine-sensitive anticonvulsant site in the rat striatum
The basal ganglia are involved in the organization of movement and function in the initiation and expression of generalized and limbic seizures. Dopamine is the principal neurotransmitter of theExpand
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