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- Publications
- Influence
Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study
- W. Turski, E. A. Cavalheiro, M. Schwarz, Stanisław J. Czuczwar, L. Turski
- Psychology, Medicine
- Behavioural Brain Research
- 1 September 1983
Behavioural, electroencephalographic and neuropathological responses to increasing doses of pilocarpine (100-400 mg/kg) administered intraperitoneally to rats were studied. At the dose of 400 mg/kg… Expand
Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy
- L. Turski, C. Ikonomidou, W. Turski, Z. Bortolotto, E. Cavalheiro
- Psychology, Medicine
- Synapse
- 1989
High‐dose treatment with pilocarpine hydrochloride, a cholinergic muscarinic agonist, induces seizures in rodents following systemic or intracerebral administration. Pilocarpine seizures are… Expand
Long‐Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures
- E. Cavalheiro, J. Leite, Z. Bortolotto, W. Turski, C. Ikonomidou, L. Turski
- Psychology, Medicine
- Epilepsia
- 1 December 1991
Summary: Structural damage of the human brain (perinatal damage, cerebral trauma, head injury, cerebrovascular and degenerative diseases, intracranial tumor, metabolic diseases, toxins, drug‐induced… Expand
Seizures produced by pilocarpine in mice: A behavioral, electroencephalographic and morphological analysis
- W. Turski, E. Cavalheiro, Z. Bortolotto, L. E. Mello, L. Turski
- Biology, Medicine
- Brain Research
- 12 November 1984
Increasing doses of pilocarpine, 100-400 mg/kg, were given intraperitoneally to mice and the resulting behavioral, electroencephalographic and neuropathological alterations were studied. No… Expand
Identification and quantification of kynurenic acid in human brain tissue
- W. Turski, M. Nakamura, W. Todd, B. Carpenter, R. Schwarcz
- Chemistry, Medicine
- Brain Research
- 28 June 1988
Serial ion-exchange and high-performance liquid chromatography separations were employed for the tissue extraction and purification of kynurenic acid (KYNA). Subsequently, the compound isolated from… Expand
Rat Brain Slices Produce and Liberate Kynurenic Acid upon Exposure to l‐Kynurenine
- W. Turski, J. B. Gramsbergen, H. Traitler, R. Schwarcz
- Biology, Medicine
- Journal of neurochemistry
- 1 May 1989
Abstract: The incorporation of l‐kynurenine (L‐KYN) into kynurenic acid (KYNA) was examined in rat brain slices. KYNA was measured in the slices and in the incubation medium after purification by… Expand
The susceptibility of rats to pilocarpine-induced seizures is age-dependent.
- E. Cavalheiro, D. F. Silva, W. Turski, L. S. Calderazzo-Filho, Z. Bortolotto, L. Turski
- Biology, Medicine
- Brain research
- 15 December 1987
Behavioral, electroencephalographic and morphological changes induced by systemic administration of pilocarpine hydrochloride were studied in 3-90-day-old rats. Pilocarpine, 100, 200 and 380 mg/kg,… Expand
Cholinomimetics produce seizures and brain damage in rats
- W. Turski, S. Czuczwar, Z. Kleinrok, L. Turski
- Biology, Medicine
- Experientia
- 15 December 1983
Microinjections of the cholinergic agonists, carbachol and bethanechol, either into the amygdala or into the dorsal hippocampus produced sustained limbic seizures and brain damage in rats. Systemic… Expand
Sedative and anticonvulsant drugs suppress postnatal neurogenesis
- V. Stefovska, O. Uckermann, +7 authors C. Ikonomidou
- Psychology, Medicine
- Annals of neurology
- 1 October 2008
Sedative and anticonvulsant drugs, which inhibit N‐methyl‐D‐aspartate receptor–mediated excitation or enhance GABA‐mediated action, may cause apoptotic neurodegeneration in the developing mammalian… Expand
Dopamine-sensitive anticonvulsant site in the rat striatum
- L. Turski, E. Cavalheiro, Z. Bortolotto, C. Ikonomidou-Turski, Z. Kleinrok, W. Turski
- Chemistry, Medicine
- The Journal of neuroscience : the official…
- 1 November 1988
The basal ganglia are involved in the organization of movement and function in the initiation and expression of generalized and limbic seizures. Dopamine is the principal neurotransmitter of the… Expand