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Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain.
Blockade of N-methyl-D-aspartate (NMDA) glutamate receptors for only a few hours during late fetal or early neonatal life triggered widespread apoptotic neurodegeneration in the developing rat brain, suggesting that the excitatory neurotransmitter glutamate, acting at NMDA receptors, controls neuronal survival.
Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study
Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy
The amygdala, thalamus, olfactory cortex, hippocampus, neocortex, and substantia nigra are the most sensitive regions to epilepsy‐related damage following convulsions produced by pilocarpine.
Autoimmune encephalomyelitis ameliorated by AMPA antagonists
It is reported that within the spinal cord in the course of autoimmune encephalomyelitis not only myelin but also neurons are subject to lymphocyte attack and may degenerate and the potential for AMPA antagonists in the therapy of multiple sclerosis is indicated.
Long‐Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures
- E. Cavalheiro, J. P. Leite, Z. Bortolotto, W. Turski, C. Ikonomidou, L. Turski
- Biology, PsychologyEpilepsia
- 1 December 1991
It is demonstrated that structural damage of the brain may lead to spontaneously recurrent convulsions (chronic epilepsy) in rats and that kindling mechanisms underlie the development of epileptic foci from structural brain lesions, which suggests thatkindling mechanisms may be involved in the etiology of some forms of epilepsy in humans.
Seizures produced by pilocarpine in mice: A behavioral, electroencephalographic and morphological analysis
Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists
It is reported that certain selective NMDA antagonists (AP7, CPP, MK-801, but not the preferential quisqualate antagonists CNQX and NBQX,8 provided short-term protection against MPP+ toxicity when coadministered into the substantia nigra.
The susceptibility of rats to pilocarpine-induced seizures is age-dependent.
NMDA antagonists potentiate antiparkinsonian actions of L‐dopa in monoamine‐depleted rats
The results make it unlikely that the neostriatum is the site of the antiparkinsonian action ofNMDA antagonists in monoamine‐depleted rats, whereas the subthalamic nucleus, internal pallidal segment, and substantia nigra pars reticulata appear to be important for the effects of NMDA antagonists.