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International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.
This article does not aim to review in detail the properties of γ-aminobutyric acidA(GABAA)breceptors, but in this same journal, a review of the binding properties and pharmacology of these receptors has been published. Expand
Antidepressants for the new millennium.
  • P. Skolnick
  • Psychology, Medicine
  • European journal of pharmacology
  • 30 June 1999
It is hypothesized that two different treatment strategies converge to produce an identical functional endpoint: a region-specific dampening of NMDA receptor function, providing a rudimentary framework for discovering novel antidepressants. Expand
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions.
The hypothesis that pathways subserved by the NMDA subtype of glutamate receptors are involved in the pathophysiology of affective disorders may have heuristic value and that substances capable of reducing neurotransmission at theNMDA receptor complex may represent a new class of antidepressants is investigated. Expand
Intra- and interstrain differences in models of “behavioral despair”
Differences in performance in the forced swim test (FST) and tail suspension test (TST) indicate that despite a face value similarity, the neurochemical pathways involved in mediating performance in these two widely used tests are not identical. Expand
Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
Findings indicate that biarylpropylsulfonamides, exemplified by LY392098, may represent a novel class of antidepressants. Expand
Differences in fear motivated behaviors among inbred mouse strains
Results indicate that genetic factors substantially contribute to fear motivated behaviors in these animal models of anxiety and the use of such inbred mouse strains may provide a novel approach to investigate the biochemical and genetic bases of fear. Expand
Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors.
The present research examined the functional effects of buspirone on D3 and D4 receptors and its ability to modify the reinforcing effects of i.v. cocaine in a behaviourally selective manner, supporting the further evaluation of busPirone as a candidate medication for the management of cocaine addiction. Expand
Glutamate and depression: clinical and preclinical studies.
Recent data indicate that a single intravenous dose of an NMDA receptor antagonist is sufficient to produce sustained relief from depressive symptoms, and these findings represent exciting and novel avenues to both understand depressive symptomatology and develop more effective antidepressants. Expand
Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor.
Preliminary evidence of a clinically meaningful antidepressant action with a molecule capable of inhibiting the three transmitters most closely linked to major depressive disorder is provided. Expand
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
The identification of a selective benzodiazepine antagonist of ethanol-stimulated 36Cl- uptake in vitro that blocks the anxiolytic and intoxicating actions ofanol suggests that many of the neuropharmacologic actions of ethanol may be mediated via central GABA receptors. Expand