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CES1 protein, human

Known as: Monocyte/Macrophage Serine Esterase, hCE1 carboxylesterase, Retinyl Ester Hydrolase 
Liver carboxylesterase 1 (567 aa, ~63 kDa) is encoded by the human CES1 gene. This protein plays a role in the catabolism of drugs and aromatic and… 
National Institutes of Health

Related topics

Related topics

11 relations
CES1 geneEndoplasmic ReticulumEnzyme GeneEsterase Gene

Broader (2)

Carboxylic Ester Hydrolasesretinyl esterase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice.
1999
1999
Carboxyl ester lipase overexpression in rat hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or metabolism of chylomicron-retinyl ester.
To study the role of carboxyl ester lipase (CEL) in hepatic retinoid (vitamin A) metabolism, we investigated uptake and… 
Highly Cited
1996
Highly Cited
1996
Oxidative tyrosylation of HDL enhances the depletion of cellular cholesteryl esters by a mechanism independent of passive sterol desorption.
It is believed that HDL protects against atherosclerosis by removing excess cholesteryl esters from cells of the artery wall… 
1996
1996
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi.
A novel acyl-CoA : cholesterol acyltransferase (ACAT) inhibitor, designated epi-cochlioquinone A has been isolated from the… 
Highly Cited
1994
Highly Cited
1994
Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase.
An enzyme with acyl coenzyme A:cholesterol acyltransferase (ACAT) activity was isolated from porcine liver, and sequences derived… 
Highly Cited
1990
Highly Cited
1990
Effects of the ACAT inhibitor CL 277,082 on cholesterol metabolism in humans
A common pharmacologic approach to lowering elevated serum cholesterol levels has been to interfere with intestinal sterol… 
Highly Cited
1989
Highly Cited
1989
Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by…
The rate of degradation of oxidatively modified low density lipoprotein (Ox-LDL) by human endothelial cells was similar to that… 
Highly Cited
1989
Highly Cited
1989
Effects of treatment with clofibrate, bezafibrate, and ciprofibrate on the metabolism of cholesterol in rat liver microsomes.
The effects of treatment of rats with clofibrate, bezafibrate, and ciprofibrate on the hepatic metabolism of cholesterol were… 
Highly Cited
1988
Highly Cited
1988
Ca++ Antagonists and ACAT Inhibitors Promote Cholesterol Efflux from Macrophages by Different Mechanisms: II. Characterization of Intracellular Morphologic Changes
The effects of the slow Ca++ channel blocker, nlfedlplne, and ACAT inhibitor, octlmlbate, on cholesterol-loaded macrophages were… 
Highly Cited
1983
Highly Cited
1983
Role of acyl CoA:cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in the rabbit.
Esterification of cholesterol in rabbit small intestine mucosal microsomes by acyl CoA:cholesterol acyltransferase (ACAT, Ec 2.3… 
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