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The opposing effects of n-3 and n-6 fatty acids.
ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.
- J. Klucken, C. Büchler, G. Schmitz
- BiologyProceedings of the National Academy of Sciences…
- 18 January 2000
It is reported here that the ATP-binding cassette (ABC) transporter ABCG1 (ABC8) is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein, defining a biologic activity for ABC transporters in Macrophages.
Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes.
Dysregulation of xenobiotic metabolism and PXR activity in the gut is likely to contribute to the pathophysiology of UC.
Absence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation.
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
Evidence is presented that TD is caused by mutations in ABC1, encoding a member of the ATP-binding cassette (ABC) transporter family, located on chromosome 9q22–31, which has implications for the understanding of cellular HDL metabolism and reverse cholesterol transport, and its association with premature cardiovascular disease.
Lipopolysaccharide and ceramide docking to CD14 provokes ligand‐specific receptor clustering in rafts
- Alexandra Pfeiffer, A. Böttcher, G. Schmitz
- Biology, MedicineEuropean journal of immunology
- 1 November 2001
Ceramide, a constituent of atherogenic lipoproteins, binds to CD14 and induces clustering of CD14 to co‐receptors in rafts and induces co‐clustering with Toll‐like receptor 4, Fcγ‐RIIIa (CD16a) and the tetraspanin CD81 while CD47 was dissociated.
Flow cytometric analysis of thiazole orange uptake by platelets: a diagnostic aid in the evaluation of thrombocytopenic disorders.
Flow cytometric analysis of platelets after staining with TO is a sensitive and specific test that rapidly provides information on the thrombopoietic activity in thromBocytopenic disorders.
Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver.
- H. Schwer, T. Langmann, R. Daig, A. Becker, C. Aslanidis, G. Schmitz
- BiologyBiochemical and biophysical research…
- 7 April 1997
Analysis of cells from the gastrointestinal tract unveiled site-specific, transcriptional regulation of iCE, with higher expression in small intestine and lower expression in colon and rectum, and high expression in jejunum compared to duodenum and ileum.
Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.
The data, demonstrating sterol-dependent regulation of hABC1 in human monocytes/macrophages, suggest a novel role for this transporter molecule in membrane lipid transport.
C(-260)-->T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction.
It is concluded that in addition to the well-established risk factors, a genetically determined reaction of monocytes/macrophages to infectious stimuli could play an important role in the process of atherosclerosis.