FAQ

CES1 gene

Known as: CES1, CES2, CEH 
This gene plays a role in the hydrolysis of aromatic and aliphatic esters.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2018
020406019762018

Related topics

Related topics

5 relations
CES1 protein, humanCES1P1 geneCES2 geneHydrolysis
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
CES1 gene
Hydrolysis
xenobiotic metabolism
CES1 protein, human
CES1P1 gene
CES2 gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins
Mammalian carboxylesterase (CES or Ces) genes encode enzymes that participate in xenobiotic, drug, and lipid metabolism in the… (More)
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2010
2010
Contrast-enhanced harmonic endoscopic ultrasound in solid lesions of the pancreas: results of a pilot study.
BACKGROUND AND STUDY AIMS Distinguishing pancreatic adenocarcinoma from other pancreatic masses remains challenging with current… (More)
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Highly Cited
2008
Highly Cited
2008
Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis.
The human carboxylesterase 1 (CES1) gene encodes for the enzyme carboxylesterase 1, a serine esterase governing both metabolic… (More)
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2008
2008
A novel perfusion imaging technique of the pancreas: contrast-enhanced harmonic EUS (with video).
BACKGROUND Contrast-enhanced harmonic-imaging techniques have been unavailable for EUS because of the limited frequency bandwidth… (More)
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Highly Cited
2007
Highly Cited
2007
Carboxylesterase in the liver and small intestine of experimental animals and human.
Native polyacrylamide gel electrophoresis showed carboxylesterase (CES) to be the most abundant hydrolase in the liver and small… (More)
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2006
2006
Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy.
BACKGROUND/AIMS Progesterone metabolites such as 5alpha-pregnan-3alpha-ol-20-one (PM4) are elevated in serum of women with… (More)
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Highly Cited
2005
Highly Cited
2005
Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.
Capecitabine is an oral prodrug of 5-fluorouracil that is indicated for the treatment of breast and colorectal cancers. A three… (More)
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2004
2004
Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin…
Carboxylesterases metabolize ester, thioester, carbamate, and amide compounds to more soluble acid, alcohol, and amine products… (More)
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2004
2004
Pharmacogenomic assessment of carboxylesterases 1 and 2.
Human carboxylesterases 1 and 2 (CES1 and CES2) catalyze the hydrolysis of many exogenous compounds. Alterations in… (More)
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1999
1999
Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol.
A microsomal triacylglycerol hydrolase (TGH) was recently purified from porcine liver [Lehner and Verger (1997) Biochemistry 36… (More)
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