Y. Tsujita

Publications104
h-index25
Citations3,380
Highly Influential Citations51
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ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium.
  • 810
  • 11
Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.
Tissue selectivity of pravastatin sodium (pravastatin) in inhibition of cholesterol synthesis was investigated and its effect was compared with other 3-hydroxy-3-methylglutaryl coenzyme A reductase… Expand
  • 167
  • 4
Tissue selectivity of pravastatin sodium, lovastatin and simvastatin. The relationship between inhibition of de novo sterol synthesis and active drug concentrations in the liver, spleen and testis in…
Tissue selectivity of pravastatin sodium (pravastatin), lovastatin and simvastatin, 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors was examined by measuring inhibition of de novo sterol… Expand
  • 61
  • 4
Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
1. ML-236A and ML-236B, potent inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, were readily absorbed into the liver, the major site of cholesterogenesis, after oral administration in mice;… Expand
  • 243
  • 3
Mechanism for elevation of hepatic cholesterol synthesis and serum cholesterol levels in triton WR-1339-induced hyperlipidemia.
Abstract 1. 1. During the first 3 h after the intravenous injection of Triton (WR-1339) to rats at a dose of 400 mg/kg (first phase), a 2-fold increase in serum cholesterol levels was accompanied by… Expand
  • 85
  • 3
The mechanism of lack of hypocholesterolemic effects of pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rats.
In order to clarify the reason why pravastatin, a 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor, did not show hypocholesterolemic effects in rats, the changes of various parameters… Expand
  • 28
  • 3
Presence and partial characterization of internal acid protease of Aspergillus oryzae.
  • Y. Tsujita, A. Endo
  • Chemistry, Medicine
  • Applied and environmental microbiology
  • 1 August 1978
The presence and partial characterization of the internal acid protease (EC 2.4.23.6) of Aspergillus oryzae has been investigated. Although the majority of the acid protease is external and present… Expand
  • 14
  • 3
CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species.
CS-514 is a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme in cholesterol synthesis. For the microsomal enzyme from rat liver, the mode of inhibition is… Expand
  • 355
  • 2
Effects of ML-236B on cholesterol metabolism in mice and rats: lack of hypocholesterolemic activity in normal animals.
ML-263B (compactin), a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, is very effective in lowering serum cholesterol levels in animal species such as hens, dogs, monkeys and man.… Expand
  • 88
  • 2
Biochemical characterization of skin fibroblasts derived from WHHL-rabbit, a notable animal model for familial hypercholesterolemia.
WHHL-rabbit (Watanabe-heritable hyperlipidemic rabbit), a strain of animal with spontaneous hyperlipidemia, is characterized by the remarkable resemblance of the pathology to type II… Expand
  • 38
  • 2