• Publications
  • Influence
C-Reactive Protein Increases Plasminogen Activator Inhibitor-1 Expression and Activity in Human Aortic Endothelial Cells: Implications for the Metabolic Syndrome and Atherothrombosis
This study makes the novel observation that CRP induces PAI-1 expression and activity in HAECs and thus has implications for both the metabolic syndrome and atherothrombosis. Expand
Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects
It is made the novel observation that TLR2 and TLR4 expression and their ligands, signaling, and functional activation are increased in recently diagnosed type 2 diabetes and contribute to the proinflammatory state. Expand
Vitamin E, oxidative stress, and inflammation.
Dietary micronutrients having anti-inflammatory and antioxidant properties and AT (at the appropriate dose and form) could have beneficial effects on cardiovascular disease in a high-risk population. Expand
High Glucose Induces Toll-Like Receptor Expression in Human Monocytes
It is suggested that high glucose induces TLR2 and -4 expression via PKC-α and PKc-δ, respectively, by stimulating NADPH oxidase in human monocytes by stimulating the expression and activity of TLRs in hyperglycemic conditions. Expand
Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States.
It is concluded that young, overtly healthy Asian Indian men have both greater insulin resistance and higher hs-CRP levels than do Caucasians, suggesting that many Asian Indians have an underlying proinflammatory state that may contribute to their increased risk for both type 2 diabetes and cardiovascular disease. Expand
Binding and Internalization of C-Reactive Protein by Fcgamma Receptors on Human Aortic Endothelial Cells Mediates Biological Effects
It is demonstrated that CRP mediates its biological effects on HAECs via binding and internalization through Fcgamma receptors, CD32 and CD64. Expand
Human C-reactive protein and the metabolic syndrome
Although a high CRP level predisposes to increased cardiovascular risk in MetS, future investigation is warranted on the in-vivo role of CRP in mediating vascular effects and resulting in increased cardiovascular events in Mets patients. Expand
CD11c/CD18 Expression Is Upregulated on Blood Monocytes During Hypertriglyceridemia and Enhances Adhesion to Vascular Cell Adhesion Molecule-1
During hypertriglyceridemia, monocytes internalize lipids, upregulate CD11c, and increase adhesion to VCAM-1, which suggests that analysis of monocyte inflammation may provide an additional framework for evaluating individual susceptibility to cardiovascular disease. Expand
Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors.
  • M. Dasu, I. Jialal
  • Biology, Medicine
  • American journal of physiology. Endocrinology and…
  • 2011
It is concluded that FFA exacerbates HG-induced TLR expression and activity in monocytic cells with excess superoxide release, enhanced NF-κB activity, and induced proinflammatory factor release. Expand
Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans.
It is concluded that cocoa products supplementation in humans affects LDL oxidizability, but not urinary F(2) isoprostanes or markers of inflammation, and there was no effect of chocolate on urinary F (2) wasoprostane levels or on markers ofinflammation. Expand