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CDK6 protein, human

Known as: cyclin-dependent kinase 6, human, PLSTIRE protein, human, Serine/Threonine-Protein Kinase PLSTIRE 
Cyclin-dependent kinase 6 (326 aa, ~37 kDa) is encoded by the human CDK6 gene. This protein plays a role in both protein phosphorylation and cell… 
National Institutes of Health

Related topics

Related topics

18 relations
CDK6 geneCell CycleCell Cycle ControlCell Nucleus

Broader (1)

cyclin-dependent kinase 6

Papers overview

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Highly Cited
2014
Highly Cited
2014
miR‐145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6
Multidrug resistance (MDR) remains a major obstacle to effective chemotherapy treatment in ovarian cancer. In our study… 
Highly Cited
2013
Highly Cited
2013
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
Chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage leukemia (MLL) trigger aberrant gene expression in… 
Highly Cited
2010
Highly Cited
2010
miR-129 regulates cell proliferation by downregulating Cdk6 expression.
Reduced expression of miR-129 has been reported in multiple tumor cell lines and in primary tumors including medulloblastoma… 
Highly Cited
2000
Highly Cited
2000
The apoptotic v-cyclin–CDK6 complex phosphorylates and inactivates Bcl-2
v-cyclin encoded by Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV or HHV8) associates with cellular cyclin-dependent… 
Highly Cited
1999
Highly Cited
1999
Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors
ABSTRACT The D-type cyclins and their major kinase partners CDK4 and CDK6 regulate G0-G1-S progression by contributing to the… 
Highly Cited
1998
Highly Cited
1998
Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells
We have performed biochemical analyses of cdk6 complexes in T cells. By gel filtration chromatography we observed at least three… 
Highly Cited
1996
Highly Cited
1996
Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.
Cyclin-dependent kinases 4 and 6 are complexed with many small cellular proteins in vivo. We have isolated cDNA sequences, INK4d… 
Highly Cited
1996
Highly Cited
1996
Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1
The cyclin D-dependent kinases CDK4 and CDK6 trigger phosphorylation of the retinoblastoma protein (RB) late in G1 phase, helping… 
Highly Cited
1996
Highly Cited
1996
Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation.
Terminal cell differentiation involves permanent withdrawal from the cell division cycle. The inhibitors of cyclin-dependent… 
Highly Cited
1995
Highly Cited
1995
Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase (*)
Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase is required for the activation of CDK enzymes… 
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