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Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders.
A novel human B-lymphotropic virus (HBLV) was isolated from the peripheral blood leukocytes of six individuals: two HTLV-III seropositive patients from the United States (one with AIDS-relatedExpand
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Differentiation of human dendritic cells from monocytes in vitro
Since either macrophages (Mϕ) or dendritic cells (DC) differentiate from monocytes (MO) depending on culture conditions, we investigated the relationship of the DC and Mϕ differentiation pathways.Expand
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The Inhibitor of Death Receptor Signaling, Flice-Inhibitory Protein Defines a New Class of Tumor Progression Factors
Death receptor–mediated apoptosis can be modulated by several antiapoptotic proteins, such as the FLICE (FADD [Fas-associated death domain]-like IL-1β–converting enzyme)-inhibitory proteins (FLIPs).Expand
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MALA‐2, mouse homologue of human adhesion molecule ICAM‐1 (CD54)
In humans, lymphocyte adhesion to cells is mediated by the protein heterodimer CD11a/CD18 (Leu‐CAMa, LFA‐1) and its ligand CD54 (ICAM‐1). Although the murine CD11a/CD18 is well characterized, theExpand
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Intracerebral inflammatory response to experimental brain contusion
SummaryThe inflammatory reaction following experimental brain contusion was studied by immunohistochemistry in 22 rats during the first 16 days after trauma. An inflammatory mononuclear cell responseExpand
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AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects.
When grown in vitro, cells from Kaposi's sarcoma lesions of AIDS patients (AIDS-KS cells) constitutively release several growth promoting activities. When inoculated into nude mice, the AIDS-KS cellsExpand
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KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.
Kaposi sarcoma (KS), an angioproliferative disease associated with Kaposi sarcoma herpesvirus (KSHV) infection, harbors a diversity of cell types ranging from endothelial to mesenchymal cells ofExpand
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Viral Oncogene–Induced DNA Damage Response Is Activated in Kaposi Sarcoma Tumorigenesis
Kaposi sarcoma is a tumor consisting of Kaposi sarcoma herpesvirus (KSHV)–infected tumor cells that express endothelial cell (EC) markers and viral genes like v-cyclin, vFLIP, and LANA. Despite aExpand
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Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells.
BACKGROUND Human herpesvirus 8 (HHV8) infection is associated with all forms of Kaposi's sarcoma (KS). The HHV8 genome locus ORFK13-72-73 (ORF = open reading frame) encodes proteins that may beExpand
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The apoptotic v-cyclin–CDK6 complex phosphorylates and inactivates Bcl-2
v-cyclin encoded by Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV or HHV8) associates with cellular cyclin-dependent kinase 6 (CDK6) to form a kinase complex that promotes cell-cycleExpand
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