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CDK6 gene

Known as: Cyclin-Dependent Kinase 6 Gene, CYCLIN-DEPENDENT KINASE 6, PLSTIRE 
This gene plays a role in the progression of the cell cycle.
National Institutes of Health

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Related topics

9 relations
CDK6 protein, humanCell Cycle ControlNegative Regulation of Cell CyclePhosphorylation

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CDK6 wt Allele

Papers overview

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Highly Cited
2017
Highly Cited
2017
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family
Circular RNAs (circRNAs) represent a class of non-coding RNAs that are widely expressed in mammals. However, it is largely… 
Highly Cited
2017
Highly Cited
2017
Circular RNA 0000096 affects cell growth and migration in gastric cancer
Background:Circular RNAs (circRNAs) are a class of non-coding RNAs broadly expressed in cells of various species. Their role in… 
Highly Cited
2016
Highly Cited
2016
Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma
Circular RNAs (circRNAs), a kind of non-coding RNAs, have shown large capabilities in gene regulation. However, the mechanisms… 
Highly Cited
2016
Highly Cited
2016
Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence
Dysregulated activation of the CDK4/6 kinases is a hallmark of most mammary-derived carcinomas. ATP-competitive inhibitors… 
Highly Cited
2013
Highly Cited
2013
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
Chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage leukemia (MLL) trigger aberrant gene expression in… 
Highly Cited
2010
Highly Cited
2010
Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM
Glioblastoma multiforme (GBM) is a fatal primary brain tumor harboring myriad genetic and epigenetic alterations. The recent… 
Highly Cited
2010
Highly Cited
2010
miR-129 regulates cell proliferation by downregulating Cdk6 expression.
Reduced expression of miR-129 has been reported in multiple tumor cell lines and in primary tumors including medulloblastoma… 
Highly Cited
2009
Highly Cited
2009
miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.
The Rb-E2F pathway drives cell cycle progression and cell proliferation, and the molecular strategies safeguarding its activity… 
Highly Cited
1994
Highly Cited
1994
Identification of G1 kinase activity for cdk6, a novel cyclin D partner
A family of vertebrate cdc2-related kinases has been identified, and these kinases are candidates for roles in cell cycle… 
Highly Cited
1994
Highly Cited
1994
CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.
Deregulated expression of cyclin D1 is a feature of several neoplastic and proliferative disorders, but its normal role in the… 
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