CDK6 gene

Known as: Cyclin-Dependent Kinase 6 Gene, CYCLIN-DEPENDENT KINASE 6, PLSTIRE 
This gene plays a role in the progression of the cell cycle.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
020406019942018

Papers overview

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2014
2014
Chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage leukemia (MLL) trigger aberrant gene expression in… (More)
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2013
Highly Cited
2013
MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated the role of miR-137 in the pathogenesis of… (More)
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2013
2013
In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high levels in lymphoid malignancies. In a… (More)
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2011
2011
The tumor suppressor p53 is a central regulator of cell-cycle arrest and apoptosis by acting as a transcription factor to… (More)
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Highly Cited
2009
Highly Cited
2009
The Rb-E2F pathway drives cell cycle progression and cell proliferation, and the molecular strategies safeguarding its activity… (More)
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2005
Highly Cited
2005
PURPOSE Medulloblastoma is the most common malignant brain tumor in children. Despite multimodal aggressive treatment, nearly… (More)
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1995
Highly Cited
1995
The cell cycle in mammalian cells is regulated by a series of cyclins and cyclin-dependent kinases (CDKs). The G1/S checkpoint is… (More)
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1994
Highly Cited
1994
A family of vertebrate cdc2-related kinases has been identified, and these kinases are candidates for roles in cell cycle… (More)
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Highly Cited
1994
Highly Cited
1994
The D-type cyclin-dependent kinases CDK4 and CDK6 are complexed with many small cellular proteins (p14, p15, p16, p18, and p20… (More)
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Highly Cited
1994
Highly Cited
1994
Deregulated expression of cyclin D1 is a feature of several neoplastic and proliferative disorders, but its normal role in the… (More)
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