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Quercetin protects rat liver against lead-induced oxidative stress and apoptosis.
Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation.
Ursolic acid administration significantly improved behavioral performance of D-gal-treated mice in step-through test and Morris water maze task and significantly decreased AGEs induced the expression of receptor for advanced glycation end products and inhibited NF-κB p65 nuclear translocation in the prefrontal cortex of D -gal- treated mice.
Purple Sweet Potato Color Alleviates D‐galactose‐induced Brain Aging in Old Mice by Promoting Survival of Neurons via PI3K Pathway and Inhibiting Cytochrome C‐mediated Apoptosis
It was demonstrated that phosphoinositide 3‐kinase (PI3K) activation was required for PSPC to promote the neuronal survival accompanied with phosphorylation and activation of Akt and p44/42 mitogen‐activated protein kinase (MAPK) by using PI3K inhibitor LY294002 by using a neuronal survival mechanism.
Quercetin activates AMP‐activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol‐induced neurotoxicity
Oral administration of quercetin significantly improved the behavioural performance of high‐cholesterol‐fed old mice in both a step‐through test and the Morris water maze task, and suggest that AMPK activated by quercETin may be a potential target to enhance the resistance of neurons to age‐related diseases.